Effectiveness of nicotine patches in relation to genotype in women versus men: randomised controlled trial

Difference in odds ratios (P value) Period of abstinence Genotype Active patch (No (%)) Placebo patch (No (%)) Odds ratio (95% confidence interval) Before adjustment After adjustment * Women 1 week CT or TT 42/93 (45) 13/90 (14) 4.9 (2.4 to 10.0) 0.001 0.001 - CC 33/125 (26) 34/137 (25) 1.1 (0.6 to 1.9) - - 12 weeks CT or TT 21/93 (23) 6/90 (7) 4.1 (1.6 to 10.7) 0.03 0.02 - CC 16/125 (13) 17/137 (12) 1.0 (0.5 to 2.2) - - 24 weeks CT or TT 17/93 (18) 5/90 (6) 3.8 (1.3 to 10.8) 0.03 0.02 - CC 12/125 (10) 15/137 (11) 0.9 (0.4 to 1.9) - - 52 weeks CT or TT 14/93 (15) 5/90 (6) 3.0 (1.0 to 8.7) 0.04 0.02 - CC 10/125 (8) 15/137 (11) 0.7 (0.3 to 1.6) - - 8 years CT or TT 11/93 (12) 4/90 (4) 2.9 (0.9 to 9.4) 0.02 0.01 - CC 6/125 (5) 13/137 (9) 0.5 (0.2 to 1.3) - - Men 1 week CT or TT 27/67 (40) 19/60 (32) 1.5 (0.7 to 3.0) 0.59 0.58 - CC 40/91 (44) 26/89 (29) 1.9 (1.0 to 3.5) 12 weeks CT or TT 17/67 (25) 11/60 (18) 1.5 (0.6 to 3.6) 0.46 0.43 - CC 21/91 (23) 10/89 (11) 2.4 (1.0 to 5.4) - - 24 weeks CT or TT 11/67 (16) 9/60 (15) 1.1 (0.4 to 2.9) 0.09 0.07 - CC 17/91 (19) 5/89 (6) 3.9 (1.4 to 11.0) - - 52 weeks CT or TT 9/67 (13) 9/60 (15) 0.9 (0.3 to 2.4) 0.07 0.07 - CC 15/91 (16) 5/89 (6) 3.3 (1.2 to 9.6) - - 8 years CT or TT 7/67 (10) 7/60 (12) 0.9 (0.3 to 2.7) 0.07 0.06 - CC 12/91 (13) 3/89 (3) 4.4 (1.2 to 16.0) - - Periods of abstinence are cumulative, with repeated biochemical confirmation.