Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell–cell adhesion complexes

STAT3 is frequently overexpressed and constitutively activated by tyrosine phosphorylation during malignant transformation. Despite the clear importance of STAT3 in cell proliferation and survival in diverse human cancers, its possible contribution to tumor cell adhesion, motility and invasion remai...

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Veröffentlicht in:Oncogene 2004-04, Vol.23 (19), p.3317-3327
Hauptverfasser: Rivat, Christine, Wever, Olivier De, Bruyneel, Erik, Mareel, Marc, Gespach, Christian, Attoub, Samir
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Sprache:eng
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