Failure of Low-Dose Atovaquone Prophylaxis against Pneumocystis jiroveci Infection in Transplant Recipients

Trimethoprim-sulfamethoxazole is the preferred agent for prophylaxis against Pneumocystis jiroveci pneumonia. Alternative agents are used in treating patients who do not tolerate this medication. We report 2 cases of prophylaxis failure in patients receiving low-dose atovaquone. We discuss the use o...

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Veröffentlicht in:	Clinical infectious diseases 2004-04, Vol.38 (8), p.e76-e78
Hauptverfasser:	Rodriguez, Martin, Sifri, Costi D., Fishman, Jay A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antifungal Agents - therapeutic use Atovaquone Chemoprevention Humans Liver Transplantation Male Middle Aged Naphthoquinones - therapeutic use Opportunistic Infections - microbiology Opportunistic Infections - prevention & control Pneumocystis carinii - drug effects Pneumocystis jiroveci Pneumonia, Pneumocystis - prevention & control Treatment Failure Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
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Zusammenfassung:	Trimethoprim-sulfamethoxazole is the preferred agent for prophylaxis against Pneumocystis jiroveci pneumonia. Alternative agents are used in treating patients who do not tolerate this medication. We report 2 cases of prophylaxis failure in patients receiving low-dose atovaquone. We discuss the use of atovaquone as an alternative agent for prophylaxis in transplant recipients.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/383150