Orf virus immuno-modulation and the host immune response
Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production an...
Gespeichert in:
| Veröffentlicht in: | Veterinary immunology and immunopathology 2002-09, Vol.87 (3), p.395-399 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 399 |
|---|---|
| container_issue | 3 |
| container_start_page | 395 |
| container_title | Veterinary immunology and immunopathology |
| container_volume | 87 |
| creator | Haig, David M Thomson, Jackie McInnes, Colin McCaughan, Catherine Imlach, Wendy Mercer, Andrew Fleming, Stephen |
| description | Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells. |
| doi_str_mv | 10.1016/S0165-2427(02)00087-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71841829</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165242702000879</els_id><sourcerecordid>71841829</sourcerecordid><originalsourceid>FETCH-LOGICAL-c392t-b6ceacbe0040bbf2e88bfdb455988b998773cfd67b01970de4a2802053d59af93</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EoqXwE0CZEAwB23FqZ0Ko4kuq1AGYLX9cVKMkLnZSiX9P0lQwdrkb7nnvTg9ClwTfEUzm9-99yVPKKL_B9BZjLHhaHKEpETxLaZ6xYzT9QyboLMavHsoLIU7RhFDMKZ2zKRKrUCZbF7qYuLruGp_W3naVap1vEtXYpF1DsvaxHceQBIgb30Q4RyelqiJc7PsMfT4_fSxe0-Xq5W3xuExNVtA21XMDymjAmGGtSwpC6NJqlg-f6KIQnGemtHOuMSk4tsAUFZjiPLN5ocoim6Hrce8m-O8OYitrFw1UlWrAd1FyIhgR9DDYczlnYgDzETTBxxiglJvgahV-JMFycCt3buUgTmIqd27lkLvaH-h0DfY_tZfZAw8jAL2PrYMgo3HQGLAugGml9e7AiV-qd4hx</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18457489</pqid></control><display><type>article</type><title>Orf virus immuno-modulation and the host immune response</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Haig, David M ; Thomson, Jackie ; McInnes, Colin ; McCaughan, Catherine ; Imlach, Wendy ; Mercer, Andrew ; Fleming, Stephen</creator><creatorcontrib>Haig, David M ; Thomson, Jackie ; McInnes, Colin ; McCaughan, Catherine ; Imlach, Wendy ; Mercer, Andrew ; Fleming, Stephen</creatorcontrib><description>Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/S0165-2427(02)00087-9</identifier><identifier>PMID: 12072264</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Ecthyma, Contagious - immunology ; Endothelial Growth Factors - genetics ; Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors ; Interleukin-10 ; Interleukin-10 - physiology ; Interleukin-2 - antagonists & inhibitors ; Lymphokines - genetics ; Poxviridae - immunology ; Poxvirus ; Sheep ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Viral Proteins - physiology</subject><ispartof>Veterinary immunology and immunopathology, 2002-09, Vol.87 (3), p.395-399</ispartof><rights>2002 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-b6ceacbe0040bbf2e88bfdb455988b998773cfd67b01970de4a2802053d59af93</citedby><cites>FETCH-LOGICAL-c392t-b6ceacbe0040bbf2e88bfdb455988b998773cfd67b01970de4a2802053d59af93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-2427(02)00087-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12072264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haig, David M</creatorcontrib><creatorcontrib>Thomson, Jackie</creatorcontrib><creatorcontrib>McInnes, Colin</creatorcontrib><creatorcontrib>McCaughan, Catherine</creatorcontrib><creatorcontrib>Imlach, Wendy</creatorcontrib><creatorcontrib>Mercer, Andrew</creatorcontrib><creatorcontrib>Fleming, Stephen</creatorcontrib><title>Orf virus immuno-modulation and the host immune response</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells.</description><subject>Animals</subject><subject>Ecthyma, Contagious - immunology</subject><subject>Endothelial Growth Factors - genetics</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors</subject><subject>Interleukin-10</subject><subject>Interleukin-10 - physiology</subject><subject>Interleukin-2 - antagonists & inhibitors</subject><subject>Lymphokines - genetics</subject><subject>Poxviridae - immunology</subject><subject>Poxvirus</subject><subject>Sheep</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Vascular Endothelial Growth Factors</subject><subject>Viral Proteins - physiology</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqXwE0CZEAwB23FqZ0Ko4kuq1AGYLX9cVKMkLnZSiX9P0lQwdrkb7nnvTg9ClwTfEUzm9-99yVPKKL_B9BZjLHhaHKEpETxLaZ6xYzT9QyboLMavHsoLIU7RhFDMKZ2zKRKrUCZbF7qYuLruGp_W3naVap1vEtXYpF1DsvaxHceQBIgb30Q4RyelqiJc7PsMfT4_fSxe0-Xq5W3xuExNVtA21XMDymjAmGGtSwpC6NJqlg-f6KIQnGemtHOuMSk4tsAUFZjiPLN5ocoim6Hrce8m-O8OYitrFw1UlWrAd1FyIhgR9DDYczlnYgDzETTBxxiglJvgahV-JMFycCt3buUgTmIqd27lkLvaH-h0DfY_tZfZAw8jAL2PrYMgo3HQGLAugGml9e7AiV-qd4hx</recordid><startdate>20020910</startdate><enddate>20020910</enddate><creator>Haig, David M</creator><creator>Thomson, Jackie</creator><creator>McInnes, Colin</creator><creator>McCaughan, Catherine</creator><creator>Imlach, Wendy</creator><creator>Mercer, Andrew</creator><creator>Fleming, Stephen</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020910</creationdate><title>Orf virus immuno-modulation and the host immune response</title><author>Haig, David M ; Thomson, Jackie ; McInnes, Colin ; McCaughan, Catherine ; Imlach, Wendy ; Mercer, Andrew ; Fleming, Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-b6ceacbe0040bbf2e88bfdb455988b998773cfd67b01970de4a2802053d59af93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Ecthyma, Contagious - immunology</topic><topic>Endothelial Growth Factors - genetics</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors</topic><topic>Interleukin-10</topic><topic>Interleukin-10 - physiology</topic><topic>Interleukin-2 - antagonists & inhibitors</topic><topic>Lymphokines - genetics</topic><topic>Poxviridae - immunology</topic><topic>Poxvirus</topic><topic>Sheep</topic><topic>Vascular Endothelial Growth Factor A</topic><topic>Vascular Endothelial Growth Factors</topic><topic>Viral Proteins - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haig, David M</creatorcontrib><creatorcontrib>Thomson, Jackie</creatorcontrib><creatorcontrib>McInnes, Colin</creatorcontrib><creatorcontrib>McCaughan, Catherine</creatorcontrib><creatorcontrib>Imlach, Wendy</creatorcontrib><creatorcontrib>Mercer, Andrew</creatorcontrib><creatorcontrib>Fleming, Stephen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haig, David M</au><au>Thomson, Jackie</au><au>McInnes, Colin</au><au>McCaughan, Catherine</au><au>Imlach, Wendy</au><au>Mercer, Andrew</au><au>Fleming, Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Orf virus immuno-modulation and the host immune response</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>2002-09-10</date><risdate>2002</risdate><volume>87</volume><issue>3</issue><spage>395</spage><epage>399</epage><pages>395-399</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>12072264</pmid><doi>10.1016/S0165-2427(02)00087-9</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-2427 |
| ispartof | Veterinary immunology and immunopathology, 2002-09, Vol.87 (3), p.395-399 |
| issn | 0165-2427 1873-2534 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71841829 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Ecthyma, Contagious - immunology Endothelial Growth Factors - genetics Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Interleukin-10 Interleukin-10 - physiology Interleukin-2 - antagonists & inhibitors Lymphokines - genetics Poxviridae - immunology Poxvirus Sheep Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Viral Proteins - physiology |
| title | Orf virus immuno-modulation and the host immune response |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T16%3A46%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Orf%20virus%20immuno-modulation%20and%20the%20host%20immune%20response&rft.jtitle=Veterinary%20immunology%20and%20immunopathology&rft.au=Haig,%20David%20M&rft.date=2002-09-10&rft.volume=87&rft.issue=3&rft.spage=395&rft.epage=399&rft.pages=395-399&rft.issn=0165-2427&rft.eissn=1873-2534&rft_id=info:doi/10.1016/S0165-2427(02)00087-9&rft_dat=%3Cproquest_cross%3E71841829%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18457489&rft_id=info:pmid/12072264&rft_els_id=S0165242702000879&rfr_iscdi=true |