Orf virus immuno-modulation and the host immune response

Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production an...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2002-09, Vol.87 (3), p.395-399
Hauptverfasser:	Haig, David M, Thomson, Jackie, McInnes, Colin, McCaughan, Catherine, Imlach, Wendy, Mercer, Andrew, Fleming, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ecthyma, Contagious - immunology Endothelial Growth Factors - genetics Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Interleukin-10 Interleukin-10 - physiology Interleukin-2 - antagonists & inhibitors Lymphokines - genetics Poxviridae - immunology Poxvirus Sheep Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Viral Proteins - physiology
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Beschreibung
Zusammenfassung:	Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells.
ISSN:	0165-2427 1873-2534
DOI:	10.1016/S0165-2427(02)00087-9