Total Synthesis of Pyridovericin: Studies toward the Biomimetic Synthesis of Pyridomacrolidin
The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.
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| Veröffentlicht in: | Organic letters 2002-06, Vol.4 (13), p.2125-2127 |
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| container_end_page | 2127 |
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| container_issue | 13 |
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| container_title | Organic letters |
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| creator | Baldwin, Jack E Adlington, Robert M Conte, Aurelia Irlapati, Nageswara Rao Marquez, Rodolfo Pritchard, Gareth J |
| description | The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine. |
| doi_str_mv | 10.1021/ol0200504 |
| format | Article |
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| ispartof | Organic letters, 2002-06, Vol.4 (13), p.2125-2127 |
| issn | 1523-7060 1523-7052 |
| language | eng |
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| source | MEDLINE; American Chemical Society Publications |
| subjects | Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Fungi - chemistry Molecular Mimicry Protein-Tyrosine Kinases - antagonists & inhibitors Pyridones - chemical synthesis Pyridones - chemistry |
| title | Total Synthesis of Pyridovericin: Studies toward the Biomimetic Synthesis of Pyridomacrolidin |
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