Total Synthesis of Pyridovericin:  Studies toward the Biomimetic Synthesis of Pyridomacrolidin

Total Synthesis of Pyridovericin:  Studies toward the Biomimetic Synthesis of Pyridomacrolidin

The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.

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Veröffentlicht in:Organic letters 2002-06, Vol.4 (13), p.2125-2127
Hauptverfasser: Baldwin, Jack E, Adlington, Robert M, Conte, Aurelia, Irlapati, Nageswara Rao, Marquez, Rodolfo, Pritchard, Gareth J
Format: Artikel
Sprache:eng
Schlagworte:
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Fungi - chemistry
Molecular Mimicry
Protein-Tyrosine Kinases - antagonists & inhibitors
Pyridones - chemical synthesis
Pyridones - chemistry
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Zusammenfassung:The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0200504