Deoxypodophyllotoxin reduces skin pigmentation of brown guinea pigs
Abstract In this report, we have demonstrated that deoxypodophyllotoxin from ANTHRISCUS SYLVESTRIS (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to do...
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| Veröffentlicht in: | Planta medica 2004-04, Vol.70 (4), p.378-380 |
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| creator | Choi, H Lee, J Shin, H.J Lee, B.G Chang, I Hwang, J.S |
| description | Abstract
In this report, we have demonstrated that deoxypodophyllotoxin from ANTHRISCUS SYLVESTRIS (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation. |
| doi_str_mv | 10.1055/s-2004-818955 |
| format | Article |
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In this report, we have demonstrated that deoxypodophyllotoxin from ANTHRISCUS SYLVESTRIS (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2004-818955</identifier><identifier>PMID: 15095159</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Administration, Cutaneous ; Animals ; Anthriscus sylvestris ; Apiaceae ; Biological and medical sciences ; deoxypodophyllotoxin ; Dermatologic Agents - administration & dosage ; Dermatologic Agents - pharmacology ; Dermatologic Agents - therapeutic use ; General pharmacology ; Guinea Pigs ; histopathology ; Letter ; lignans ; Medical sciences ; melanin ; naphthalene ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytochemicals ; Phytotherapy ; pigmentation ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Roots ; Podophyllotoxin - administration & dosage ; Podophyllotoxin - analogs & derivatives ; Podophyllotoxin - pharmacology ; Podophyllotoxin - therapeutic use ; skin ; Skin Pigmentation - drug effects ; Skin Pigmentation - radiation effects ; Ultraviolet Rays</subject><ispartof>Planta medica, 2004-04, Vol.70 (4), p.378-380</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-e0d812f70d71b24e3d6ab6559080eed45de7a1379eedbe67b9b767388492fb593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2004-818955.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2004-818955$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,778,782,3006,3007,27907,27908,54542,54543</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15707854$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15095159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, H</creatorcontrib><creatorcontrib>Lee, J</creatorcontrib><creatorcontrib>Shin, H.J</creatorcontrib><creatorcontrib>Lee, B.G</creatorcontrib><creatorcontrib>Chang, I</creatorcontrib><creatorcontrib>Hwang, J.S</creatorcontrib><title>Deoxypodophyllotoxin reduces skin pigmentation of brown guinea pigs</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
In this report, we have demonstrated that deoxypodophyllotoxin from ANTHRISCUS SYLVESTRIS (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation.</description><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>Anthriscus sylvestris</subject><subject>Apiaceae</subject><subject>Biological and medical sciences</subject><subject>deoxypodophyllotoxin</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Dermatologic Agents - pharmacology</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>General pharmacology</subject><subject>Guinea Pigs</subject><subject>histopathology</subject><subject>Letter</subject><subject>lignans</subject><subject>Medical sciences</subject><subject>melanin</subject><subject>naphthalene</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytochemicals</subject><subject>Phytotherapy</subject><subject>pigmentation</subject><subject>plant extracts</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Podophyllotoxin - administration & dosage</subject><subject>Podophyllotoxin - analogs & derivatives</subject><subject>Podophyllotoxin - pharmacology</subject><subject>Podophyllotoxin - therapeutic use</subject><subject>skin</subject><subject>Skin Pigmentation - drug effects</subject><subject>Skin Pigmentation - radiation effects</subject><subject>Ultraviolet Rays</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10UtPxCAUBWBiNDo-lm61G11ZvZRSYGnGZ2LiQl0T2t6O1bZUaOPMv5dJJ9GNK3LDxyEcCDmmcEmB8ysfJwBpLKlUnG-RGU2ZiiFJ6DaZAbAkBpWyPbLv_QcATRXALtmjHBSnXM3I_AbtctXb0vbvq6axg13WXeSwHAv0kf8MQ18vWuwGM9S2i2wV5c5-d9FirDs0601_SHYq03g82qwH5O3u9nX-ED893z_Or5_igkkYYoRS0qQSUAqaJymyMjN5xrkCCYhlyksUhjKhwpBjJnKVi0wwKVOVVDlX7ICcT7m9s18j-kG3tS-waUyHdvRaUBlOCxFgPMHCWe8dVrp3dWvcSlPQ69a01-vW9NRa8Ceb4DFvsfzVm5oCONsA4wvTVM50Re3_OAFC8jS4i8kN7zW2qD_s6LpQyb_3nk68MlabhQuRby8JUAbh07IsPOcHjfKL9w</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Choi, H</creator><creator>Lee, J</creator><creator>Shin, H.J</creator><creator>Lee, B.G</creator><creator>Chang, I</creator><creator>Hwang, J.S</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>Deoxypodophyllotoxin reduces skin pigmentation of brown guinea pigs</title><author>Choi, H ; Lee, J ; Shin, H.J ; Lee, B.G ; Chang, I ; Hwang, J.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-e0d812f70d71b24e3d6ab6559080eed45de7a1379eedbe67b9b767388492fb593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Administration, Cutaneous</topic><topic>Animals</topic><topic>Anthriscus sylvestris</topic><topic>Apiaceae</topic><topic>Biological and medical sciences</topic><topic>deoxypodophyllotoxin</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Dermatologic Agents - pharmacology</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>General pharmacology</topic><topic>Guinea Pigs</topic><topic>histopathology</topic><topic>Letter</topic><topic>lignans</topic><topic>Medical sciences</topic><topic>melanin</topic><topic>naphthalene</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytochemicals</topic><topic>Phytotherapy</topic><topic>pigmentation</topic><topic>plant extracts</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Podophyllotoxin - administration & dosage</topic><topic>Podophyllotoxin - analogs & derivatives</topic><topic>Podophyllotoxin - pharmacology</topic><topic>Podophyllotoxin - therapeutic use</topic><topic>skin</topic><topic>Skin Pigmentation - drug effects</topic><topic>Skin Pigmentation - radiation effects</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, H</creatorcontrib><creatorcontrib>Lee, J</creatorcontrib><creatorcontrib>Shin, H.J</creatorcontrib><creatorcontrib>Lee, B.G</creatorcontrib><creatorcontrib>Chang, I</creatorcontrib><creatorcontrib>Hwang, J.S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, H</au><au>Lee, J</au><au>Shin, H.J</au><au>Lee, B.G</au><au>Chang, I</au><au>Hwang, J.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deoxypodophyllotoxin reduces skin pigmentation of brown guinea pigs</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>70</volume><issue>4</issue><spage>378</spage><epage>380</epage><pages>378-380</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
In this report, we have demonstrated that deoxypodophyllotoxin from ANTHRISCUS SYLVESTRIS (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>15095159</pmid><doi>10.1055/s-2004-818955</doi><tpages>3</tpages></addata></record> |
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| subjects | Administration, Cutaneous Animals Anthriscus sylvestris Apiaceae Biological and medical sciences deoxypodophyllotoxin Dermatologic Agents - administration & dosage Dermatologic Agents - pharmacology Dermatologic Agents - therapeutic use General pharmacology Guinea Pigs histopathology Letter lignans Medical sciences melanin naphthalene Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Phytotherapy pigmentation plant extracts Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Podophyllotoxin - administration & dosage Podophyllotoxin - analogs & derivatives Podophyllotoxin - pharmacology Podophyllotoxin - therapeutic use skin Skin Pigmentation - drug effects Skin Pigmentation - radiation effects Ultraviolet Rays |
| title | Deoxypodophyllotoxin reduces skin pigmentation of brown guinea pigs |
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