Deoxypodophyllotoxin reduces skin pigmentation of brown guinea pigs

Abstract In this report, we have demonstrated that deoxypodophyllotoxin from ANTHRISCUS SYLVESTRIS (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to do...

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Veröffentlicht in:	Planta medica 2004-04, Vol.70 (4), p.378-380
Hauptverfasser:	Choi, H, Lee, J, Shin, H.J, Lee, B.G, Chang, I, Hwang, J.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Anthriscus sylvestris Apiaceae Biological and medical sciences deoxypodophyllotoxin Dermatologic Agents - administration & dosage Dermatologic Agents - pharmacology Dermatologic Agents - therapeutic use General pharmacology Guinea Pigs histopathology Letter lignans Medical sciences melanin naphthalene Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Phytotherapy pigmentation plant extracts Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Podophyllotoxin - administration & dosage Podophyllotoxin - analogs & derivatives Podophyllotoxin - pharmacology Podophyllotoxin - therapeutic use skin Skin Pigmentation - drug effects Skin Pigmentation - radiation effects Ultraviolet Rays
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Beschreibung
Zusammenfassung:	Abstract In this report, we have demonstrated that deoxypodophyllotoxin from ANTHRISCUS SYLVESTRIS (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2004-818955