Calculating sample size bounds for logistic regression

The calculation of a study’s required sample size is one of the most important aspects of the validity of an epidemiological study. Logistic regression often is used in modelling in epidemiology. A simplified method to calculate the sample size for the multiple logistic-regression model was proposed by Hsieh et al. [Stat. Med. 17 (1998) 1623]. The approach for estimating the sample size is described and then applied in the planning of an epidemiological cross-sectional study of the associations of different risk factors with Toxoplasma infection among pregnant women. Although the method demands some additional information which is often difficult to obtain, it is a very useful tool in veterinary epidemiology.