Biaryl amide glucagon receptor antagonists

Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-05, Vol.14 (9), p.2047-2050
Hauptverfasser:	KURUKULASURIYA, Ravi, SORENSEN, Bryan K, ADLER, Andrew L, COLLINS, Christine A, LINK, James T, PATEL, Jyoti R, JAE, Hwan-Soo, WINN, Marty X, ROHDE, Jeffrey R, GRIHALDE, Nelson D, LIN, Chun W, OGIELA, Christopher A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - pharmacology Animals Biological and medical sciences General and cellular metabolism. Vitamins Haplorhini Humans Medical sciences Mice Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptors, Glucagon - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.02.056