Discovery of substituted 3,4-Diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol

Substituted 3,4-diphenyl-1,3-thiazols were identified as a class of novel and potent monoamine transporter inhibitors through a 3-D pharmacophore search using a new pharmacophore model derived from mazindol. The most potent compound ( 13) has K i values of 24 and 23 nM in binding to dopamine transporter and inhibition of dopamine reuptake, respectively. 3,4-Diphenyl-thiazoles were identified as a novel class of monoamine transporter inhibitors ( K i=24 nM at DAT).