Alpha-fetoprotein- and des-gamma-carboxy prothrombin-producing advanced gastric cancer

A case of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) producing gastric cancer with multiple liver metastasis is reported. The simultaneous presence of Borrmann I gastric cancer and IIa aggregating type gastric cancer was noted. Borrmann I gastric cancer was a poorly differentiat...

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Veröffentlicht in:	European journal of gastroenterology & hepatology 2002-06, Vol.14 (6), p.687-691
Hauptverfasser:	Ando, Eiji, Oriishi, Tetsuharu, Toyonaga, Atsushi, Tobaru, Takeshi, Tanaka, Masatoshi, Shimamura, Ryuji, Terai, Yuji, Nakajima, Yutaka, Sata, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism alpha-Fetoproteins - biosynthesis Biological and medical sciences Biomarkers Biomarkers, Tumor - biosynthesis Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Liver Neoplasms - secondary Male Medical sciences Middle Aged Protein Precursors - biosynthesis Prothrombin - biosynthesis Stomach Neoplasms - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Zusammenfassung:	A case of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) producing gastric cancer with multiple liver metastasis is reported. The simultaneous presence of Borrmann I gastric cancer and IIa aggregating type gastric cancer was noted. Borrmann I gastric cancer was a poorly differentiated adenocarcinoma, while IIa aggregating type gastric cancer was a moderately differentiated adenocarcinoma. Plasma levels of AFP and DCP were 247 000 ng/ml and 320 000 mAU/ml, respectively. Immunohistochemical staining confirmed the production of these two proteins in Borrmann I gastric cancer.
ISSN:	0954-691X 1473-5687
DOI:	10.1097/00042737-200206000-00015