Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia

Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia

Malarial anemia involves destruction of parasitized and non-parasitized red blood cells and dyserythropoiesis. Malarial pigment, hemozoin (HZ), is possibly implicated in dyserythropoiesis. We show that supernatants of HZ and HZ-fed-monocytes, and 4-hydroxynonenal generated by them, inhibited progeni...

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Veröffentlicht in:Haematologica (Roma) 2004-04, Vol.89 (4), p.492-493
Hauptverfasser: Giribaldi, G, Ulliers, D, Schwarzer, E, Roberts, I, Piacibello, W, Arese, P
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - pharmacology
Anemia - etiology
Animals
Cells, Cultured
Erythropoiesis - drug effects
Hemeproteins - pharmacology
Humans
Malaria - blood
Plasmodium - chemistry
Plasmodium - pathogenicity
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Zusammenfassung:Malarial anemia involves destruction of parasitized and non-parasitized red blood cells and dyserythropoiesis. Malarial pigment, hemozoin (HZ), is possibly implicated in dyserythropoiesis. We show that supernatants of HZ and HZ-fed-monocytes, and 4-hydroxynonenal generated by them, inhibited progenitor growth.
ISSN:0390-6078
1592-8721