Usefulness of cytokines interleukin-6 and interleukin-2R concentrations in diagnosing active infective endocarditis involving native valves

The most important diagnostic value in infective endocarditis (IE) is isolation of the causative microorganism. Because premature antibiotic treatment is commonly administered before the assessment of blood cultures, the percentages of isolated microorganisms has decreased significantly within the last decades. Therefore, additional criteria for the diagnosis of IE may be helpful. It was hypothesized that assessment of interleukin-6 (IL-6) and interleukin-2R (IL-2R) may provide new diagnostic criteria for inflammation in IE. IL-6 and IL-2R serum concentrations, white blood cell count (WBC), and C-reactive protein (CRP) were measured in the blood of 47 patients with IE at the time of diagnosis and during treatment. WBC and CRP were elevated in patients with IE at the time of diagnosis. Both parameters were higher (p