Dihydroceramide desaturase activity in tumors

Dihydroceramide desaturase activity in the transplantable mouse hepatoma-22, rat hepatoma-27, M1 sarcoma, and RS1 rat cholangiocellular carcinoma has been investigated. It was found that the dihydroceramide desaturase activity in mouse hepatoma-22 is lower than that in normal mouse liver. However, t...

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Veröffentlicht in:	Biochemistry (Moscow) 2002-05, Vol.67 (5), p.597-599
Hauptverfasser:	Kandyba, A G, Kobliakov, V A, Kozlov, A M, Nagaev, I Yu, Shevchenko, V P, Dyatlovitskaya, E V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - metabolism Enzymatic activity Injections, Subcutaneous Liver - enzymology Liver Neoplasms - enzymology Liver Neoplasms - metabolism Mice Neoplasm Transplantation Oxidoreductases - metabolism Rats Rodents Sarcoma Sarcoma - enzymology Sarcoma - metabolism Sphingosine - analogs & derivatives Sphingosine - metabolism Tumors
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Zusammenfassung:	Dihydroceramide desaturase activity in the transplantable mouse hepatoma-22, rat hepatoma-27, M1 sarcoma, and RS1 rat cholangiocellular carcinoma has been investigated. It was found that the dihydroceramide desaturase activity in mouse hepatoma-22 is lower than that in normal mouse liver. However, the activity of this enzyme in subcutaneously and intrahepatically transplanted rat hepatoma-27 is increased compared to normal value. Dihydroceramide desaturase activity in subcutaneously and intrahepatically transplanted M1 sarcoma as well as in hepatoma-27 is dependent on the tumor microenvironment. The enzyme activity in RS1 tumor was not revealed. The data indicate that dihydroceramide desaturase activity depends on the tumor type and its microenvironment.
ISSN:	0006-2979 1608-3040
DOI:	10.1023/A:1015562615341