Graves' ophthalmopathy evolution studied by MRI during childhood and adolescence

Pediatric patients with Graves' disease (n = 26) were studied longitudinally by magnetic resonance imaging of the orbits, allowing an assessment of the enlargement of the extraocular muscles and orbital volume variations. The positive outcome of Graves' ophthalmopathy correlated with low T...

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Veröffentlicht in:	The Journal of pediatrics 2004-04, Vol.144 (4), p.527-531
Hauptverfasser:	Antoniazzi, Franco, Zamboni, Giorgio, Cerini, Roberto, Lauriola, Silvana, Dall'Agnola, Alberto, Tatò, Luciano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Child Child, Preschool Disease Progression Endocrinopathies Exophthalmos - pathology Female Graves Disease - pathology Graves Disease - physiopathology Humans Longitudinal Studies Magnetic Resonance Imaging Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Oculomotor Muscles - growth & development Oculomotor Muscles - pathology Orbit - growth & development Orbit - pathology Puberty - physiology Receptors, Thyrotropin - blood Reference Values Thyroid. Thyroid axis (diseases)
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Zusammenfassung:	Pediatric patients with Graves' disease (n = 26) were studied longitudinally by magnetic resonance imaging of the orbits, allowing an assessment of the enlargement of the extraocular muscles and orbital volume variations. The positive outcome of Graves' ophthalmopathy correlated with low TRAb (autoantibodies to thyroid-stimulating hormone receptor) titers at diagnosis and during follow-up and with prepubertal condition at diagnosis.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2004.01.033