Detecting multi-drug resistance of bladder cancer for the intravesical chemotherapy

Detecting multi-drug resistance of bladder cancer for the intravesical chemotherapy

To explore multi-drug resistance (MDR) of bladder cancer for the intravesical instillation. Using immunohistochemical staining, in 44-case human bladder cancer cells, the expressions of P-glycoprotein (P-gp), glutathione S-transferase (GST-pi) and topoisomerase (TOPO-II), were detected to find out t...

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Veröffentlicht in:Chung-hua wai kʿo tsa chih 2004-03, Vol.42 (5), p.285-287
Hauptverfasser: Kang, Xin-li, Geng, Zhen-hong, Lu, Xing-xiang, Wei, Chao, Wang, Jin-gang, Wang, San-zhong, Ma, Sen, Liu, Hong-xin, Xu, Guo-ying, Zhang, Hua-wei, Wang, Guo-yong
Format: Artikel
Sprache:chi
Schlagworte:
Administration, Intravesical
Adult
Aged
ATP-Binding Cassette, Sub-Family B, Member 1 - analysis
DNA Topoisomerases, Type II - analysis
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Female
Glutathione Transferase - analysis
Humans
Immunohistochemistry
Male
Middle Aged
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - metabolism
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Zusammenfassung:To explore multi-drug resistance (MDR) of bladder cancer for the intravesical instillation. Using immunohistochemical staining, in 44-case human bladder cancer cells, the expressions of P-glycoprotein (P-gp), glutathione S-transferase (GST-pi) and topoisomerase (TOPO-II), were detected to find out the resistance to drugs. P-gp had a higher expression in 54.5% cases. GST-pi had no or a lower expression in 65.9% cases. TOPO-II had a higher expression in 29.5% but a lower expression in 65.9% cases. Detecting the factors of MDR in bladder cancer cells could help to choose drugs for intravesical chemotherapy.
ISSN:0529-5815