Genomics to fluxomics and physiomics — pathway engineering

Developments in microanalytical methods are enabling quantitative measurement of multiple metabolic fluxes and, in conjunction with transcript and proteomic profiling, are revolutionizing the ability of researchers to manipulate metabolism through pathway engineering in a variety of species. We review recent literature on the advances in genomics, proteomics, fluxomics and computational modeling focused on metabolic pathway engineering applications. The coalescence of genomics, proteomics, fluxomics and computational tools are driving major advances in pathway engineering, and it is happening now. This review provides a snapshot of some of the most recent scientific literature, and documents the increasing sophistication and power of metabolic engineering technology applicable to industrial, medical and agricultural opportunities.