South-East Asian ovalocytosis among the population of the Highlands of Madagascar: a vestige of the island's settlement

In the Madagascar Highlands, 0·76% of children from 168 random primary schools, and 19 of 150 families from 3 villages, had oval-shaped erythrocytes. Most harboured the deletion in the band 3 gene characteristic of South-East Asian ovalocytosis. This genetic trait supports the Indonesian origin of t...

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Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 2002-03, Vol.96 (2), p.143-144
Hauptverfasser:	Rabe, T., Jambou, R., Rabarijaona, L., Raharimalala, L., Rason, M.A., Ariey, F., Dhermy, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adults Altitude Anemias. Hemoglobinopathies Biological and medical sciences Child Cross-Sectional Studies Diseases of red blood cells Elliptocytosis, Hereditary - epidemiology Elliptocytosis, Hereditary - genetics Emigration and Immigration erythrocytes Gene Deletion genetic traits Hematologic and hematopoietic diseases Humans Indonesia Madagascar Madagascar - epidemiology Medical sciences Mutation - genetics Polymerase Chain Reaction - methods Prevalence schoolchildren South-East Asian ovalocytosis Tropical medicine
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Zusammenfassung:	In the Madagascar Highlands, 0·76% of children from 168 random primary schools, and 19 of 150 families from 3 villages, had oval-shaped erythrocytes. Most harboured the deletion in the band 3 gene characteristic of South-East Asian ovalocytosis. This genetic trait supports the Indonesian origin of the Madagascar settlement.
ISSN:	0035-9203 1878-3503
DOI:	10.1016/S0035-9203(02)90282-8