Structures of Glycopeptide Antibiotics with Peptides that Model Bacterial Cell-Wall Precursors

The vancomycin-related antibiotics balhimycin and degluco-balhimycin have been crystallized in complexes with di-, tri- and pentapeptides that emulate bacterial cell-wall precursors, and four structures determined at atomic resolution (

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular biology 2002-05, Vol.318 (3), p.723-732
Hauptverfasser:	Lehmann, Christopher, Bunkóczi, Gábor, Vértesy, László, Sheldrick, George M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry bacterial cell-wall Bacterial Proteins - chemistry Binding Sites Cell Wall - chemistry crystal structure Crystallography, X-Ray Dimerization Drug Resistance, Bacterial glycopeptide antibiotics Ligands Models, Molecular Molecular Structure peptide complexes Protein Conformation Protein Precursors - chemistry vancomycin Vancomycin - analogs & derivatives Vancomycin - chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The vancomycin-related antibiotics balhimycin and degluco-balhimycin have been crystallized in complexes with di-, tri- and pentapeptides that emulate bacterial cell-wall precursors, and four structures determined at atomic resolution (
ISSN:	0022-2836 1089-8638
DOI:	10.1016/S0022-2836(02)00146-8