Mortality and causes of death in Crohn's disease: Follow-up of a population-based cohort in Copenhagen County, Denmark

Background & Aims: A population-based cohort comprising 374 patients with Crohn's disease diagnosed in Copenhagen County between 1962 and 1987 was observed until 1997 for mortality and causes of death. Methods: Observed deaths were compared with expected deaths calculated by using individually computed person-years at risk and 1995 rates for Copenhagen County. Cumulative survival curves were calculated. Results: A total of 84 deaths occurred vs. 67 expected (standardized mortality ratio [SMR], 1.3; 95% confidence interval [CI], 1.01–1.56): 45 women vs. 31.8 expected (SMR, 1.4; 95% CI, 1.03–1.89) and 39 men vs. 35.2 expected (SMR, 1.1; 95% CI, 0.79–1.51). An excess mortality was observed among women observed for 21–25 years after diagnosis. Among women aged