Synthesis of the Furanosteroidal Antibiotic Viridin

A rhodium‐catalyzed alkyne cyclotrimerization, domino electrocyclic reactions, and a hydroxy‐directed dihydroxylation are key steps in an efficient synthesis of the bioactive furanosteroid viridin (1) from a simple acyclic triyne.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2004-04, Vol.43 (15), p.1998-2001
Hauptverfasser:	Anderson, Edward A., Alexanian, Erik J., Sorensen, Erik J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstenes - chemical synthesis Androstenes - chemistry Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Bacteriocins - chemical synthesis Bacteriocins - chemistry cyclotrimerization dihydroxylation electrocyclic reactions inhibitors Molecular Structure natural products Polycyclic Compounds - chemical synthesis Polycyclic Compounds - chemistry
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Beschreibung
Zusammenfassung:	A rhodium‐catalyzed alkyne cyclotrimerization, domino electrocyclic reactions, and a hydroxy‐directed dihydroxylation are key steps in an efficient synthesis of the bioactive furanosteroid viridin (1) from a simple acyclic triyne.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200353129