Asymmetric Direct Aldol Reaction Assisted by Water and a Proline-Derived Tetrazole Catalyst

Just add water to improve the performance of direct aldol reactions like that shown. Previously, aldehydes with high water‐affinity or ‐solubility were considered unsuitable for asymmetric synthesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2004-04, Vol.43 (15), p.1983-1986
Hauptverfasser:	Torii, Hiromi, Nakadai, Masakazu, Ishihara, Kazuaki, Saito, Susumu, Yamamoto, Hisashi
Format:	Artikel
Sprache:	eng
Schlagworte:	aldol reaction amines asymmetric catalysis Catalysis Formaldehyde - chemistry Ketones - chemistry Molecular Structure Proline - chemistry Stereoisomerism tetrazole Tetrazoles - chemistry water Water - chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Just add water to improve the performance of direct aldol reactions like that shown. Previously, aldehydes with high water‐affinity or ‐solubility were considered unsuitable for asymmetric synthesis.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200352724