Increased orderliness of growth hormone (GH) secretion in GH-deficient adults with low serum insulin-like growth factor I

Increased orderliness of growth hormone (GH) secretion in GH-deficient adults with low serum insulin-like growth factor I

Available studies suggest that a proportion of GH-deficient (GHD) adults maintain serum IGF-I concentrations within the age- and sex-matched normal range. The basis for this distinction is not known. In this study 24-h GH profiles (sampling every 30 min) were appraised in five GHD adults with low se...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism 2002-06, Vol.87 (6), p.2863-2869
Hauptverfasser: SVENSSON, Johan, VELDHUIS, Johannes D, IRANMANESH, Ali, BENGTSSON, Bengt-Ake, JOHANNSSON, Gudmundur
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Endocrinopathies
Entropy
Female
Human Growth Hormone - deficiency
Human Growth Hormone - secretion
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Insulin-Like Growth Factor I - metabolism
Male
Medical sciences
Metabolism, Inborn Errors - metabolism
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Osmolar Concentration
Reference Values
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Zusammenfassung:Available studies suggest that a proportion of GH-deficient (GHD) adults maintain serum IGF-I concentrations within the age- and sex-matched normal range. The basis for this distinction is not known. In this study 24-h GH profiles (sampling every 30 min) were appraised in five GHD adults with low serum IGF-I concentrations (
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.87.6.2863