Two New Diterpenoids from Ballota limbata

Two new clerodane-type diterpenoids trivially named as ballotenic acid (1) and ballodiolic acid (2) have been isolated from Ballota limbata along with three the known compounds; β-amyrin, oleanolic acid, and β-sitosterol. The structure elucidation of the new compounds was based primarily on two-dime...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2004, Vol.52(4), pp.441-443
Hauptverfasser:	Ahmad, Viqar Uddin, Farooq, Umar, Hussain, Javid, Ullah, Farman, Nawaz, Sarfraz Ahmad, Choudhary, Muhammad Iqbal
Format:	Artikel
Sprache:	eng
Schlagworte:	Ballota - chemistry Ballota limbata clerodane diterpenoid Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Diterpenes, Clerodane - chemistry Diterpenes, Clerodane - isolation & purification Diterpenes, Clerodane - pharmacology Indicators and Reagents Lamiaceae Lipoxygenase Inhibitors - chemistry Lipoxygenase Inhibitors - isolation & purification Lipoxygenase Inhibitors - pharmacology lipoxygenase inhibitory assay Magnetic Resonance Spectroscopy Mass Spectrometry Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Structure-Activity Relationship
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Zusammenfassung:	Two new clerodane-type diterpenoids trivially named as ballotenic acid (1) and ballodiolic acid (2) have been isolated from Ballota limbata along with three the known compounds; β-amyrin, oleanolic acid, and β-sitosterol. The structure elucidation of the new compounds was based primarily on two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect (NOE) experiments. Compounds 1 and 2 displayed inhibitory potential against lipoxygenase enzyme in a concentration-dependent fashion with IC50 values of 99.6 μM and 38.3 μM, respectively.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.52.441