The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice

We evaluated the efficacy of three dietary interventions started at middle age (14 months) to retard the aging process in mice. These were supplemental alpha-lipoic acid (LA) or coenzyme Q(10) (CQ) and caloric restriction (CR, a positive control). LA and CQ had no impact on longevity or tumor patter...

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Veröffentlicht in:	Free radical biology & medicine 2004-04, Vol.36 (8), p.1043-1057
Hauptverfasser:	Lee, Cheol-Koo, Pugh, Thomas D, Klopp, Roger G, Edwards, Jode, Allison, David B, Weindruch, Richard, Prolla, Tomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Antioxidants - chemistry Antioxidants - pharmacology Body Weight Caloric Restriction Coenzymes Complement System Proteins Cytosol - metabolism Dietary Supplements Extracellular Matrix - metabolism Free Radicals Gene Expression Regulation Longevity - genetics Major Histocompatibility Complex - genetics Male Mice Mice, Inbred C3H Mice, Inbred C57BL Myocardium - metabolism Oligonucleotide Array Sequence Analysis Oligonucleotides - chemistry Oxidative Stress Oxygen - metabolism Phosphorylation RNA - metabolism Thioctic Acid - metabolism Time Factors Transcription, Genetic Ubiquinone - analogs & derivatives Ubiquinone - metabolism
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Zusammenfassung:	We evaluated the efficacy of three dietary interventions started at middle age (14 months) to retard the aging process in mice. These were supplemental alpha-lipoic acid (LA) or coenzyme Q(10) (CQ) and caloric restriction (CR, a positive control). LA and CQ had no impact on longevity or tumor patterns compared with control mice fed the same number of calories, whereas CR increased maximum life span by 13% (p
ISSN:	0891-5849
DOI:	10.1016/j.freeradbiomed.2004.01.015