Effects of intraaortic balloon augmentation in a porcine model of endotoxemic shock

Objective: Patients with septic shock commonly have myocardial dysfunction associated with lactic acid production and troponin I release. The purpose of this study was to evaluate the effects on intraaortic balloon pump (IABP) support on myocardial dysfunction. Design: Prospective, randomized contro...

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Veröffentlicht in:	Resuscitation 2004-03, Vol.60 (3), p.319-326
Hauptverfasser:	Engoren, Milo, Habib, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidose láctica Acidosis láctica Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Balão de contrapulsão intra-aortico Biological and medical sciences Bomba de balón intraaórtico Choque séptico Disease Models, Animal Endotoxemia Female Flujo sanguı́neo miocárdico Fluxo sanguı́neo no miocárdio Intensive care medicine Intra-Aortic Balloon Pumping Intraaortic balloon pump Lactic Acid - blood Lactic acidosis Male Medical sciences Myocardial blood flow Prospective Studies Random Allocation Septic shock Shock séptico Shock, Septic - therapy Swine Troponin I
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Zusammenfassung:	Objective: Patients with septic shock commonly have myocardial dysfunction associated with lactic acid production and troponin I release. The purpose of this study was to evaluate the effects on intraaortic balloon pump (IABP) support on myocardial dysfunction. Design: Prospective, randomized controlled study. Setting: Animal research laboratory. Methods: Ten pigs had arterial, pulmonary arterial, and coronary catheters inserted. After receiving endotoxin infusion over 30 min, half the animals received IABP support. Results: Coronary sinus lactic acid levels ( P
ISSN:	0300-9572 1873-1570
DOI:	10.1016/j.resuscitation.2003.10.008