The Ovariectomized Sheep as a Model for Human Bone Loss

The Ovariectomized Sheep as a Model for Human Bone Loss

The aim of this study was to determine the effects of ovariectomy on the trabeculae of ovine iliac bone, with a view to the further development of a model for human osteoporosis. Seven ovariectomized (OVX) and five control Dorset ewes were observed for one year. Iliac crest bone samples were obtaine...

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Veröffentlicht in:Journal of comparative pathology 2004-05, Vol.130 (4), p.323-326
Hauptverfasser: Newton, B.I, Cooper, R.C, Gilbert, J.A, Johnson, R.B, Zardiackas, L.D
Format: Artikel
Sprache:eng
Schlagworte:
animal model
Animals
bone
deoxypyridinium
Disease Models, Animal
Estradiol - analysis
Female
Humans
oestradiol
osteocalcin
Osteocalcin - analysis
osteoporosis
Osteoporosis - pathology
Ovariectomy
Pelvic Bones - pathology
Pyridinium Compounds - urine
Sheep
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Beschreibung
Zusammenfassung:The aim of this study was to determine the effects of ovariectomy on the trabeculae of ovine iliac bone, with a view to the further development of a model for human osteoporosis. Seven ovariectomized (OVX) and five control Dorset ewes were observed for one year. Iliac crest bone samples were obtained at the time of ovariectomy (“time 0”) and again when the animals were killed 12 months later. At “time 0” and at 3-month intervals thereafter samples of blood and urine were collected for the assay of serum 17β-oestradiol and osteocalcin (OC) and urinary deoxypyridinium (D-PYR). One year after ovariectomy, trabecular bone volume and thickness were reduced ( P
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2003.12.007