Infectious enteritis after intestinal transplantation: incidence, timing, and outcome
To review the incidence, timing, and outcome of infectious enteritis after intestinal transplantation (IT). A retrospective review of all patients undergoing IT at a single institution between 1991 and 2003 was analyze with standard statistical tools. Among 33 IT recipients, 13 (39%) developed 20 cu...
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| Veröffentlicht in: | Transplantation proceedings 2004-03, Vol.36 (2), p.379-380 |
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| creator | Ziring, D Tran, R Edelstein, S McDiarmid, S.V Vargas, J Cortina, G Gajjar, N Ching, N Cherry, J Krogstad, P Renz, J.F Fondevila, C Busuttil, R.W Farmer, D.G |
| description | To review the incidence, timing, and outcome of infectious enteritis after intestinal transplantation (IT).
A retrospective review of all patients undergoing IT at a single institution between 1991 and 2003 was analyze with standard statistical tools.
Among 33 IT recipients, 13 (39%) developed 20 culture- or biopsy-proven episodes of infectious enteritis. The recipient demographics were 77% men and median age 2.6 years. Infections were diagnosed at a median of 76 days (32 to 1800) after IT. There were 14 viral (CMV one, rotavirus eight, adenovirus four, EBV one, three bacterial (
Clostridium difficile), and three other infections (
Giardia lamblia one, cryptosporidium two). Complete resolution was achieved in 17 (94%) infectious after appropriate antimicrobial or conservative therapy. Interestingly, there were six rejection episodes following infectious enteritis. Grafts were lost to rejection after rotaviral enteritis (
n = 1) and adenoviral enteritis misdiagnosed as rejection (
n = 1). Patient and graft survival were not adversely affected by infections.
Infectious enteritis occurs frequently after IT. Viral agents are the cause in two-thirds of cases. With supportive care and appropriate treatment, resolution is possible in the majority of cases. Differentiating rejection and infection by histopathology can be difficult. |
| doi_str_mv | 10.1016/j.transproceed.2004.01.093 |
| format | Article |
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A retrospective review of all patients undergoing IT at a single institution between 1991 and 2003 was analyze with standard statistical tools.
Among 33 IT recipients, 13 (39%) developed 20 culture- or biopsy-proven episodes of infectious enteritis. The recipient demographics were 77% men and median age 2.6 years. Infections were diagnosed at a median of 76 days (32 to 1800) after IT. There were 14 viral (CMV one, rotavirus eight, adenovirus four, EBV one, three bacterial (
Clostridium difficile), and three other infections (
Giardia lamblia one, cryptosporidium two). Complete resolution was achieved in 17 (94%) infectious after appropriate antimicrobial or conservative therapy. Interestingly, there were six rejection episodes following infectious enteritis. Grafts were lost to rejection after rotaviral enteritis (
n = 1) and adenoviral enteritis misdiagnosed as rejection (
n = 1). Patient and graft survival were not adversely affected by infections.
Infectious enteritis occurs frequently after IT. Viral agents are the cause in two-thirds of cases. With supportive care and appropriate treatment, resolution is possible in the majority of cases. Differentiating rejection and infection by histopathology can be difficult.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2004.01.093</identifier><identifier>PMID: 15050165</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Bacterial Infections - epidemiology ; Biological and medical sciences ; Child ; Enteritis - epidemiology ; Female ; Humans ; Intestines - microbiology ; Intestines - transplantation ; Male ; Medical sciences ; Postoperative Complications - microbiology ; Postoperative Complications - virology ; Retrospective Studies ; Stomach, duodenum, intestine, rectum, anus ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Time Factors ; Treatment Outcome ; Virus Diseases - epidemiology</subject><ispartof>Transplantation proceedings, 2004-03, Vol.36 (2), p.379-380</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-755eda59953508ed16ada7dfdd69d7c5b05ddb0f0a733b858fc3f6992c379e543</citedby><cites>FETCH-LOGICAL-c408t-755eda59953508ed16ada7dfdd69d7c5b05ddb0f0a733b858fc3f6992c379e543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2004.01.093$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>310,311,315,782,786,791,792,3552,23937,23938,25147,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15621959$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15050165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ziring, D</creatorcontrib><creatorcontrib>Tran, R</creatorcontrib><creatorcontrib>Edelstein, S</creatorcontrib><creatorcontrib>McDiarmid, S.V</creatorcontrib><creatorcontrib>Vargas, J</creatorcontrib><creatorcontrib>Cortina, G</creatorcontrib><creatorcontrib>Gajjar, N</creatorcontrib><creatorcontrib>Ching, N</creatorcontrib><creatorcontrib>Cherry, J</creatorcontrib><creatorcontrib>Krogstad, P</creatorcontrib><creatorcontrib>Renz, J.F</creatorcontrib><creatorcontrib>Fondevila, C</creatorcontrib><creatorcontrib>Busuttil, R.W</creatorcontrib><creatorcontrib>Farmer, D.G</creatorcontrib><title>Infectious enteritis after intestinal transplantation: incidence, timing, and outcome</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>To review the incidence, timing, and outcome of infectious enteritis after intestinal transplantation (IT).
A retrospective review of all patients undergoing IT at a single institution between 1991 and 2003 was analyze with standard statistical tools.
Among 33 IT recipients, 13 (39%) developed 20 culture- or biopsy-proven episodes of infectious enteritis. The recipient demographics were 77% men and median age 2.6 years. Infections were diagnosed at a median of 76 days (32 to 1800) after IT. There were 14 viral (CMV one, rotavirus eight, adenovirus four, EBV one, three bacterial (
Clostridium difficile), and three other infections (
Giardia lamblia one, cryptosporidium two). Complete resolution was achieved in 17 (94%) infectious after appropriate antimicrobial or conservative therapy. Interestingly, there were six rejection episodes following infectious enteritis. Grafts were lost to rejection after rotaviral enteritis (
n = 1) and adenoviral enteritis misdiagnosed as rejection (
n = 1). Patient and graft survival were not adversely affected by infections.
Infectious enteritis occurs frequently after IT. Viral agents are the cause in two-thirds of cases. With supportive care and appropriate treatment, resolution is possible in the majority of cases. Differentiating rejection and infection by histopathology can be difficult.</description><subject>Adult</subject><subject>Bacterial Infections - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Enteritis - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Intestines - microbiology</subject><subject>Intestines - transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Postoperative Complications - microbiology</subject><subject>Postoperative Complications - virology</subject><subject>Retrospective Studies</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Virus Diseases - epidemiology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1rGzEQQEVpqZ20fyEshfbk3Uir1WrlW0jS1BDIpTkLWRoVmV2tI8mF_PuOsQk59iQN8-ZDT4R8Y7RhlPXXu6YkE_M-zRbANS2lXUNZQxX_QJZskLxu-5Z_JEtMsJrxTizIRc47inHb8c9kwQQV2EksyfMmerAlzIdcQSyQQgm5Mh5vVcA4lxDNWJ0GjiYWg2xcY84GB9HCqiphCvHPqjLRVfOh2HmCL-STN2OGr-fzkjz_vP99-6t-fHrY3N481rajQ6mlEOCMUEpwQQdwrDfOSOed65WTVmypcG5LPTWS8-0gBm-575VqLZcKRMcvyY9TX3TxcsBl9RSyhREXBXyRlkwOvZQ9gusTaNOccwKv9ylMJr1qRvVRqt7p91L1UaqmTKNULL46TzlsJ8y9lZ4tIvD9DJhszeixkQ35Hde3TAmF3N2JA3TyN0DS2YajRBcSfoJ2c_ifff4BAi2eMA</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Ziring, D</creator><creator>Tran, R</creator><creator>Edelstein, S</creator><creator>McDiarmid, S.V</creator><creator>Vargas, J</creator><creator>Cortina, G</creator><creator>Gajjar, N</creator><creator>Ching, N</creator><creator>Cherry, J</creator><creator>Krogstad, P</creator><creator>Renz, J.F</creator><creator>Fondevila, C</creator><creator>Busuttil, R.W</creator><creator>Farmer, D.G</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Infectious enteritis after intestinal transplantation: incidence, timing, and outcome</title><author>Ziring, D ; Tran, R ; Edelstein, S ; McDiarmid, S.V ; Vargas, J ; Cortina, G ; Gajjar, N ; Ching, N ; Cherry, J ; Krogstad, P ; Renz, J.F ; Fondevila, C ; Busuttil, R.W ; Farmer, D.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-755eda59953508ed16ada7dfdd69d7c5b05ddb0f0a733b858fc3f6992c379e543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Bacterial Infections - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Enteritis - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Intestines - microbiology</topic><topic>Intestines - transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Postoperative Complications - microbiology</topic><topic>Postoperative Complications - virology</topic><topic>Retrospective Studies</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Virus Diseases - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ziring, D</creatorcontrib><creatorcontrib>Tran, R</creatorcontrib><creatorcontrib>Edelstein, S</creatorcontrib><creatorcontrib>McDiarmid, S.V</creatorcontrib><creatorcontrib>Vargas, J</creatorcontrib><creatorcontrib>Cortina, G</creatorcontrib><creatorcontrib>Gajjar, N</creatorcontrib><creatorcontrib>Ching, N</creatorcontrib><creatorcontrib>Cherry, J</creatorcontrib><creatorcontrib>Krogstad, P</creatorcontrib><creatorcontrib>Renz, J.F</creatorcontrib><creatorcontrib>Fondevila, C</creatorcontrib><creatorcontrib>Busuttil, R.W</creatorcontrib><creatorcontrib>Farmer, D.G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ziring, D</au><au>Tran, R</au><au>Edelstein, S</au><au>McDiarmid, S.V</au><au>Vargas, J</au><au>Cortina, G</au><au>Gajjar, N</au><au>Ching, N</au><au>Cherry, J</au><au>Krogstad, P</au><au>Renz, J.F</au><au>Fondevila, C</au><au>Busuttil, R.W</au><au>Farmer, D.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infectious enteritis after intestinal transplantation: incidence, timing, and outcome</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>36</volume><issue>2</issue><spage>379</spage><epage>380</epage><pages>379-380</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>To review the incidence, timing, and outcome of infectious enteritis after intestinal transplantation (IT).
A retrospective review of all patients undergoing IT at a single institution between 1991 and 2003 was analyze with standard statistical tools.
Among 33 IT recipients, 13 (39%) developed 20 culture- or biopsy-proven episodes of infectious enteritis. The recipient demographics were 77% men and median age 2.6 years. Infections were diagnosed at a median of 76 days (32 to 1800) after IT. There were 14 viral (CMV one, rotavirus eight, adenovirus four, EBV one, three bacterial (
Clostridium difficile), and three other infections (
Giardia lamblia one, cryptosporidium two). Complete resolution was achieved in 17 (94%) infectious after appropriate antimicrobial or conservative therapy. Interestingly, there were six rejection episodes following infectious enteritis. Grafts were lost to rejection after rotaviral enteritis (
n = 1) and adenoviral enteritis misdiagnosed as rejection (
n = 1). Patient and graft survival were not adversely affected by infections.
Infectious enteritis occurs frequently after IT. Viral agents are the cause in two-thirds of cases. With supportive care and appropriate treatment, resolution is possible in the majority of cases. Differentiating rejection and infection by histopathology can be difficult.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15050165</pmid><doi>10.1016/j.transproceed.2004.01.093</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1345 |
| ispartof | Transplantation proceedings, 2004-03, Vol.36 (2), p.379-380 |
| issn | 0041-1345 1873-2623 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Bacterial Infections - epidemiology Biological and medical sciences Child Enteritis - epidemiology Female Humans Intestines - microbiology Intestines - transplantation Male Medical sciences Postoperative Complications - microbiology Postoperative Complications - virology Retrospective Studies Stomach, duodenum, intestine, rectum, anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Time Factors Treatment Outcome Virus Diseases - epidemiology |
| title | Infectious enteritis after intestinal transplantation: incidence, timing, and outcome |
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