The presence of more than two index adenomas is the strongest predictor of metachronous colon adenomas
To assess whether patient or adenoma characteristics at index colonoscopy could be predictors of metachronous adenomas and of advanced metachronous adenomas at first surveillance colonoscopy. This retrospective study evaluated polypectomies of 372 adenomas in 214 patients who underwent a first follo...
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| Veröffentlicht in: | Swiss medical weekly 2002-03, Vol.132 (11-12), p.139-142 |
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| container_title | Swiss medical weekly |
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| creator | Külling, Daniel Christ, Andreas D Karaaslan, Nidayi Fried, Michael Bauerfeind, Peter |
| description | To assess whether patient or adenoma characteristics at index colonoscopy could be predictors of metachronous adenomas and of advanced metachronous adenomas at first surveillance colonoscopy.
This retrospective study evaluated polypectomies of 372 adenomas in 214 patients who underwent a first follow-up colonoscopy after a median of 17 months. Logistic regression analysis was used to assess the association of baseline patient and adenoma characteristics with the development of any metachronous adenomas and of advanced adenomas (>1.0 cm, or villous component, or severe dysplasia, or early cancer).
Eighty-one patients (38%) demonstrated 130 metachronous adenomas including 21 cases (10%) with advanced adenomas. The presence of more than 2 baseline adenomas was significantly associated with the finding of adenomas at follow-up (odds ratio 2.44, 95% confidence interval 1.27-4.68, p = 0.010). Patient age (>or= 60 versus 1.0 cm versus |
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This retrospective study evaluated polypectomies of 372 adenomas in 214 patients who underwent a first follow-up colonoscopy after a median of 17 months. Logistic regression analysis was used to assess the association of baseline patient and adenoma characteristics with the development of any metachronous adenomas and of advanced adenomas (>1.0 cm, or villous component, or severe dysplasia, or early cancer).
Eighty-one patients (38%) demonstrated 130 metachronous adenomas including 21 cases (10%) with advanced adenomas. The presence of more than 2 baseline adenomas was significantly associated with the finding of adenomas at follow-up (odds ratio 2.44, 95% confidence interval 1.27-4.68, p = 0.010). Patient age (>or= 60 versus <60) and size of largest adenoma (>1.0 cm versus <or= 1.0 cm) demonstrated borderline significance. However, neither gender, most advanced histology (tubulo-villous/villous versus tubular), nor most advanced dysplasia (severe/early cancer versus mild/moderate) at baseline colonoscopy were related with the development of metachronous adenomas. Furthermore, none of the analysed patient and polyp characteristics demonstrated an association with the development of advanced metachronous adenomas.
Patients with over 2 adenomas at baseline colonoscopy are at highest risk for the finding of adenomas at follow-up.</description><identifier>ISSN: 1424-7860</identifier><identifier>PMID: 12046004</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Adenoma - epidemiology ; Adenoma - pathology ; Adenoma - surgery ; Adult ; Aged ; Aged, 80 and over ; Colonic Polyps - epidemiology ; Colonic Polyps - pathology ; Colonic Polyps - surgery ; Colonoscopy ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Neoplasms, Second Primary - epidemiology ; Neoplasms, Second Primary - pathology ; Odds Ratio ; Predictive Value of Tests ; Retrospective Studies ; Switzerland - epidemiology</subject><ispartof>Swiss medical weekly, 2002-03, Vol.132 (11-12), p.139-142</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12046004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Külling, Daniel</creatorcontrib><creatorcontrib>Christ, Andreas D</creatorcontrib><creatorcontrib>Karaaslan, Nidayi</creatorcontrib><creatorcontrib>Fried, Michael</creatorcontrib><creatorcontrib>Bauerfeind, Peter</creatorcontrib><title>The presence of more than two index adenomas is the strongest predictor of metachronous colon adenomas</title><title>Swiss medical weekly</title><addtitle>Swiss Med Wkly</addtitle><description>To assess whether patient or adenoma characteristics at index colonoscopy could be predictors of metachronous adenomas and of advanced metachronous adenomas at first surveillance colonoscopy.
This retrospective study evaluated polypectomies of 372 adenomas in 214 patients who underwent a first follow-up colonoscopy after a median of 17 months. Logistic regression analysis was used to assess the association of baseline patient and adenoma characteristics with the development of any metachronous adenomas and of advanced adenomas (>1.0 cm, or villous component, or severe dysplasia, or early cancer).
Eighty-one patients (38%) demonstrated 130 metachronous adenomas including 21 cases (10%) with advanced adenomas. The presence of more than 2 baseline adenomas was significantly associated with the finding of adenomas at follow-up (odds ratio 2.44, 95% confidence interval 1.27-4.68, p = 0.010). Patient age (>or= 60 versus <60) and size of largest adenoma (>1.0 cm versus <or= 1.0 cm) demonstrated borderline significance. However, neither gender, most advanced histology (tubulo-villous/villous versus tubular), nor most advanced dysplasia (severe/early cancer versus mild/moderate) at baseline colonoscopy were related with the development of metachronous adenomas. Furthermore, none of the analysed patient and polyp characteristics demonstrated an association with the development of advanced metachronous adenomas.
Patients with over 2 adenomas at baseline colonoscopy are at highest risk for the finding of adenomas at follow-up.</description><subject>Adenoma - epidemiology</subject><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Colonic Polyps - epidemiology</subject><subject>Colonic Polyps - pathology</subject><subject>Colonic Polyps - surgery</subject><subject>Colonoscopy</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms, Second Primary - epidemiology</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Switzerland - epidemiology</subject><issn>1424-7860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAYhD2AaCn9C8gTWyR_OxlRxZdUiaXMkWO_aYISO9iOgH9PgMJ0w91zOt0ZWlPBRKFLRVboMqVXQlipqLxAK8qIUISINWoPHeApQgJvAYcWjyECzp3xOL8H3HsHH9g48GE0CfdpsQCnHIM_QsrfpOttDvEHhWxst1hhTtiGIfh_8gqdt2ZIsD3pBr3c3x12j8X--eFpd7svJsqrXFScEq6tttRZIYFxZVWpWsJF01CjiXWSSWuoY9JUtGpKJoQwSjZctcoSzTfo5rd3iuFtXhbWY58sDIPxsKyqNdWlFEQtwetTcG5GcPUU-9HEz_rvGf4F6spfSw</recordid><startdate>20020323</startdate><enddate>20020323</enddate><creator>Külling, Daniel</creator><creator>Christ, Andreas D</creator><creator>Karaaslan, Nidayi</creator><creator>Fried, Michael</creator><creator>Bauerfeind, Peter</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020323</creationdate><title>The presence of more than two index adenomas is the strongest predictor of metachronous colon adenomas</title><author>Külling, Daniel ; Christ, Andreas D ; Karaaslan, Nidayi ; Fried, Michael ; Bauerfeind, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-931037c7c1dc45e236c686f034bb1a70cd525ca1d25a919b82444a65b36f6c073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adenoma - epidemiology</topic><topic>Adenoma - pathology</topic><topic>Adenoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Colonic Polyps - epidemiology</topic><topic>Colonic Polyps - pathology</topic><topic>Colonic Polyps - surgery</topic><topic>Colonoscopy</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms, Second Primary - epidemiology</topic><topic>Neoplasms, Second Primary - pathology</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Switzerland - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Külling, Daniel</creatorcontrib><creatorcontrib>Christ, Andreas D</creatorcontrib><creatorcontrib>Karaaslan, Nidayi</creatorcontrib><creatorcontrib>Fried, Michael</creatorcontrib><creatorcontrib>Bauerfeind, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Swiss medical weekly</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Külling, Daniel</au><au>Christ, Andreas D</au><au>Karaaslan, Nidayi</au><au>Fried, Michael</au><au>Bauerfeind, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The presence of more than two index adenomas is the strongest predictor of metachronous colon adenomas</atitle><jtitle>Swiss medical weekly</jtitle><addtitle>Swiss Med Wkly</addtitle><date>2002-03-23</date><risdate>2002</risdate><volume>132</volume><issue>11-12</issue><spage>139</spage><epage>142</epage><pages>139-142</pages><issn>1424-7860</issn><abstract>To assess whether patient or adenoma characteristics at index colonoscopy could be predictors of metachronous adenomas and of advanced metachronous adenomas at first surveillance colonoscopy.
This retrospective study evaluated polypectomies of 372 adenomas in 214 patients who underwent a first follow-up colonoscopy after a median of 17 months. Logistic regression analysis was used to assess the association of baseline patient and adenoma characteristics with the development of any metachronous adenomas and of advanced adenomas (>1.0 cm, or villous component, or severe dysplasia, or early cancer).
Eighty-one patients (38%) demonstrated 130 metachronous adenomas including 21 cases (10%) with advanced adenomas. The presence of more than 2 baseline adenomas was significantly associated with the finding of adenomas at follow-up (odds ratio 2.44, 95% confidence interval 1.27-4.68, p = 0.010). Patient age (>or= 60 versus <60) and size of largest adenoma (>1.0 cm versus <or= 1.0 cm) demonstrated borderline significance. However, neither gender, most advanced histology (tubulo-villous/villous versus tubular), nor most advanced dysplasia (severe/early cancer versus mild/moderate) at baseline colonoscopy were related with the development of metachronous adenomas. Furthermore, none of the analysed patient and polyp characteristics demonstrated an association with the development of advanced metachronous adenomas.
Patients with over 2 adenomas at baseline colonoscopy are at highest risk for the finding of adenomas at follow-up.</abstract><cop>Switzerland</cop><pmid>12046004</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Swiss medical weekly, 2002-03, Vol.132 (11-12), p.139-142 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Alma/SFX Local Collection |
| subjects | Adenoma - epidemiology Adenoma - pathology Adenoma - surgery Adult Aged Aged, 80 and over Colonic Polyps - epidemiology Colonic Polyps - pathology Colonic Polyps - surgery Colonoscopy Female Humans Logistic Models Male Middle Aged Neoplasms, Second Primary - epidemiology Neoplasms, Second Primary - pathology Odds Ratio Predictive Value of Tests Retrospective Studies Switzerland - epidemiology |
| title | The presence of more than two index adenomas is the strongest predictor of metachronous colon adenomas |
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