Needle revision of failing and failed trabeculectomy blebs with adjunctive 5-fluorouracil: Survival analysis

To report the outcome of 5-fluorouracil (5-FU)–augmented bleb needling revision of failed and failing filtration blebs and to identify risk factors for failure, indicators for success, and any complications of the procedure. Prospective, observational, noncomparative, interventional case series with survival analysis. The results of 101 bleb needling procedures augmented with subconjunctival 5-FU injection were determined after a minimum follow-up of 9 months. Kaplan–Meier plots were constructed and a Cox proportional hazards regression analysis was performed to assess the association between study factors and time to failure. Reduction in intraocular pressure (IOP) by 2 criteria (30%), glaucoma medications, complications, and factors associated with outcome. At the time of their last follow-up visit, 60 eyes had an IOP