Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat

Multidrug resistance-associated protein 4 (Mrp4, ABCC4) transports cyclic nucleotides, anti-retroviral compounds, and sulfated bile acids. Mrp4 expression is increased in farnesyl/bile acid receptor knockout mice. Our aim was to investigate Mrp4 expression and function in rat liver and kidney in obs...

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Veröffentlicht in:	Journal of hepatology 2004-04, Vol.40 (4), p.585-591
Hauptverfasser:	Denk, Gerald U, Soroka, Carol J, Takeyama, Yasuaki, Chen, Wen-Sheng, Schuetz, John D, Boyer, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-binding cassette transporter Base Sequence Bile acids Bile Acids and Salts - blood Bile Acids and Salts - urine Bile duct ligation Biological and medical sciences Cholestasis - genetics Cholestasis - metabolism Cyclic adenosine monophosphate Cyclic AMP - blood Cyclic AMP - urine Cyclic nucleotides DNA - genetics Down-Regulation Gastroenterology. Liver. Pancreas. Abdomen Immunohistochemistry Kidney - metabolism Liver - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Multidrug resistance-associated protein 4 Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Other diseases. Semiology Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Up-Regulation
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