Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing–remitting MS

To understand the short-term dynamics of the circulating T cell receptor V beta (TCRBV) repertoire in relapsing–remitting multiple sclerosis (MS), we monitored the TCRBV profiles of untreated MS patients and healthy controls. Expansions of TCRBV genes in MS patients were significantly more frequent...

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Veröffentlicht in:	Journal of neuroimmunology 2002-06, Vol.127 (1), p.149-159
Hauptverfasser:	Muraro, P.A., Bonanni, L., Mazzanti, B., Pantalone, A., Traggiai, E., Massacesi, L., Vergelli, M., Gambi, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Female Gene Expression - immunology Humans Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - immunology Immunoglobulins Magnetic Resonance Imaging Male Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - immunology Multiple Sclerosis, Relapsing-Remitting - pathology Myelin basic protein Myelin Basic Protein - immunology Oligoclonal Bands Polymorphism, Single-Stranded Conformational Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology RNA, Messenger - analysis Single-strand conformational polymorphism T cell receptors T-Lymphocytes - immunology
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Zusammenfassung:	To understand the short-term dynamics of the circulating T cell receptor V beta (TCRBV) repertoire in relapsing–remitting multiple sclerosis (MS), we monitored the TCRBV profiles of untreated MS patients and healthy controls. Expansions of TCRBV genes in MS patients were significantly more frequent than in controls ( P
ISSN:	0165-5728 1872-8421
DOI:	10.1016/S0165-5728(02)00105-4