Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia

Summary Aim : To investigate a motilin effect on gallbladder volume in healthy volunteers and patients with functional dyspepsia. Methods : Forty‐three healthy volunteers and 10 patients with functional dyspepsia received motilin (4 pmol.min/kg) or placebo in four separate double‐blind, randomized, placebo‐controlled, cross‐over studies. The gallbladder volume was measured by ultrasonography. Analysis of variance of the combined data of these studies was performed to investigate a motilin effect on gallbladder volume and potential differences between patients and healthy volunteers. Results : The baseline gallbladder volume was similar for placebo and motilin treatment, as well as for patients and healthy volunteers. Motilin, compared with placebo, significantly decreased the gallbladder volume in healthy volunteers (P = 0.003) and patients (P