The use of carbon paste electrode in the direct voltammetric determination of tryptophan in pharmaceutical formulations

A simple, fast and sensitive method is proposed for Tryptophan (Trp) determination in pharmaceutical formulations containing other non-electroative aminoacids, vitamins and hydroxycobalamines. Optimized conditions for differential pulse voltammetry allowed the determination of Trp with detection lim...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2002-06, Vol.28 (5), p.909-915
Hauptverfasser:	Fiorucci, Antonio Rogério, Cavalheiro, Éder Tadeu Gomes
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Ascorbic Acid - chemistry Biological and medical sciences Buffers Carbon Carbon paste electrode Differential pulse voltammetry Drug Combinations Electrochemistry Electrodes General pharmacology Indicators and Reagents Medical sciences Pharmacology. Drug treatments Tablets Tryptophan Tryptophan - analysis
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Beschreibung
Zusammenfassung:	A simple, fast and sensitive method is proposed for Tryptophan (Trp) determination in pharmaceutical formulations containing other non-electroative aminoacids, vitamins and hydroxycobalamines. Optimized conditions for differential pulse voltammetry allowed the determination of Trp with detection limit of 1.7 μM in 2–30 mM linear dynamic range ( n=7; r=0.999), at a bare, non-treated carbon paste electrode. Ascorbic acid interference was evaluated and eliminated by choosing a suitable baseline for determination of peak currents for Trp.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/S0731-7085(01)00711-7