Diagnostic Testing for Hepatitis C

ABSTRACT Diagnostic tests for hepatitis C virus have improved dramatically over the past decade. Highly accurate tests are now available for screening patients for possible hepatitis C infections and confirming the presence of active viral infection. HCV RNA levels and genotype are very useful in assessing the likelihood of response to antiviral therapy and in guiding the optimum duration of treatment. Absence of detectable HCV RNA using PCR methodology has become the gold standard of successful treatment of patients with chronic hepatitis C. The various tests for hepatitis C are expensive and have their limitations. However, selective use of these assays has greatly improved the care of patients with chronic hepatitis C.