Ketene acetal and spiroacetal constituents of the marine fungus Aigialus parvus BCC 5311

Aigialone (1) and aigialospirol (2), two structurally unique compounds, were isolated from the mangrove fungus Aigialus parvus BCC 5311. The structure of the new ketene acetal 1 was elucidated by spectral analysis, and its relative stereochemistry was determined by X-ray crystallography. The stereoc...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.457-460
Hauptverfasser:	Vongvilai, P, Isaka, M, Kittakoop, P, Srikitikulchai, P, Kongsaeree, P, Thebtaranonth, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetals - chemistry Acetals - isolation & purification Acetals - pharmacology Aigialus parvus Ascomycota - chemistry Benzofurans - chemistry Benzofurans - isolation & purification Benzofurans - pharmacology Biological and medical sciences Brackish Crystallography, X-Ray Ethylenes General pharmacology Ketones - chemistry Ketones - isolation & purification Ketones - pharmacology Marine Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Stereoisomerism Thailand Zearalenone - analogs & derivatives Zearalenone - chemistry Zearalenone - pharmacology
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Zusammenfassung:	Aigialone (1) and aigialospirol (2), two structurally unique compounds, were isolated from the mangrove fungus Aigialus parvus BCC 5311. The structure of the new ketene acetal 1 was elucidated by spectral analysis, and its relative stereochemistry was determined by X-ray crystallography. The stereochemistry of aigialospirol (2), elucidated by NMR spectral analysis, suggested that this compound is possibly derived from hypothemycin (3), a metabolite previously isolated from this same fungus.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np030344d