Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders

Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders

We studied polymorphisms of mitochondrial DNA 5178cytosine/adenine (mt5178C/A) and angiotensin I-converting enzyme (ACE) genes ( DCP1) in 127 cerebrovascular disorder (CVD) patients and 294 age-matched normal controls to clarify the genetic background of Japanese patients with CVD. Mt5178C was predo...

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Veröffentlicht in:Journal of the neurological sciences 2002-06, Vol.198 (1), p.31-35
Hauptverfasser: Ohkubo, Ryuichi, Nakagawa, Masanori, Ikeda, Ken-ichi, Kodama, Tomoko, Arimura, Kimiyoshi, Akiba, Suminori, Saito, Minoru, Ookatsu, Yosuke, Atsuchi, Yoshihiko, Yamano, Yoshihisa, Osame, Mitsuhiro
Format: Artikel
Sprache:eng
Schlagworte:
ACE
Aged
Aged, 80 and over
Aging
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Cerebrovascular disorders
Cerebrovascular Disorders - etiology
Cerebrovascular Disorders - genetics
DNA, Mitochondrial - genetics
Female
Gene Frequency
Humans
Japan
Male
Medical sciences
Middle Aged
Mitochondrial DNA
Neurology
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Reference Values
Risk Factors
Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:We studied polymorphisms of mitochondrial DNA 5178cytosine/adenine (mt5178C/A) and angiotensin I-converting enzyme (ACE) genes ( DCP1) in 127 cerebrovascular disorder (CVD) patients and 294 age-matched normal controls to clarify the genetic background of Japanese patients with CVD. Mt5178C was predominant in CVD patients compared with controls ( P
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(02)00055-2