Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvatio...

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Veröffentlicht in:	Nature genetics 2002-06, Vol.31 (2), p.133-134
Hauptverfasser:	Powers, Scott, Li, Jing, Yang, Ying, Peng, Yue, Austin, Richard J, van Eyndhoven, Winfried G, Nguyen, Ken C. Q, Gabriele, Tim, McCurrach, Mila E, Marks, Jeffrey R, Hoey, Timothy, Lowe, Scott W
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Apoptosis - genetics Biological and medical sciences Biomedicine Breast cancer Breast Neoplasms - etiology Breast Neoplasms - genetics brief-communication Cancer cells Cancer Research Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - genetics Chromosomes, Human, Pair 17 - genetics Female Fundamental and applied biological sciences. Psychology Gene Amplification Gene expression Gene Function Genetic aspects Human Genetics Humans Molecular and cellular biology Neoplasm Proteins Oncogenes - genetics Phosphoprotein Phosphatases - genetics Physiological aspects PPM1D gene Protein Phosphatase 2C RAS gene
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Zusammenfassung:	We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng888