Chronic exercise is associated with enhanced cutaneous blood flow in Type 2 diabetes
Impaired blood flow to skin contributes to foot ulceration and amputation. The overall objective of this cross-sectional study was to examine the relationship between chronic physical activity and skin blood flow in Type 2 diabetes. To do so, diabetic and control subjects were separated into four gr...
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| Veröffentlicht in: | Journal of diabetes and its complications 2002-03, Vol.16 (2), p.139-145 |
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| creator | Colberg, Sheri R Stansberry, Kevin B McNitt, Patricia M Vinik, Aaron I |
| description | Impaired blood flow to skin contributes to foot ulceration and amputation. The overall objective of this cross-sectional study was to examine the relationship between chronic physical activity and skin blood flow in Type 2 diabetes. To do so, diabetic and control subjects were separated into four groups based on a physical activity questionnaire: control exerciser (CE), control sedentary (CS), diabetic exerciser (DE), and diabetic sedentary (DS) subjects. After a physical exam and neuropathic testing, skin blood flow was measured noninvasively by continuous laser Doppler assessment of lower limb blood flow in response to various stimuli. Both groups of exercisers had enhanced baseline and ischemia reperfusion (IRP)-induced blood flow. Significant differences in maximal neurogenic dorsal foot skin perfusion were also present (
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| doi_str_mv | 10.1016/S1056-8727(01)00222-7 |
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P<.05): CE had greater perfusion than either diabetic group, but CS blood flow was higher than DS only. Since, nitric oxide (NO) is a potent vasodilator, concurrent real-time measurements of NO in cutaneous interstitial fluids were recorded. No significant differences in maximal levels of NO were found among the four groups during any flow condition. Fasting serum glucose levels and HbA
1c were significantly inversely correlated with skin blood flow during heating. Chronic exercise is associated with enhanced skin blood under certain flow conditions in Type 2 diabetes compared with the sedentary state. As such, regular physical activity may be an invaluable tool in the prevention and reversal of defective skin vasodilation and resultant foot ulcers so common in diabetes.</description><identifier>ISSN: 1056-8727</identifier><identifier>EISSN: 1873-460X</identifier><identifier>DOI: 10.1016/S1056-8727(01)00222-7</identifier><identifier>PMID: 12039396</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Analysis of Variance ; Biological and medical sciences ; Blood flow ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - physiopathology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Exercise - physiology ; Exercise training ; Female ; Foot ; Humans ; Hyperglycemia ; Male ; Management. Various non-drug treatments. Langerhans islet grafts ; Medical sciences ; Middle Aged ; Nitric oxide ; Regional Blood Flow - physiology ; Skin - blood supply ; Skin - innervation ; Surveys and Questionnaires ; Type 2 diabetes</subject><ispartof>Journal of diabetes and its complications, 2002-03, Vol.16 (2), p.139-145</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-dbdd395849a715e0f738dc542215cb5b99b6cc045753aedae5c654199722b13d3</citedby><cites>FETCH-LOGICAL-c443t-dbdd395849a715e0f738dc542215cb5b99b6cc045753aedae5c654199722b13d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1056-8727(01)00222-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13599231$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12039396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colberg, Sheri R</creatorcontrib><creatorcontrib>Stansberry, Kevin B</creatorcontrib><creatorcontrib>McNitt, Patricia M</creatorcontrib><creatorcontrib>Vinik, Aaron I</creatorcontrib><title>Chronic exercise is associated with enhanced cutaneous blood flow in Type 2 diabetes</title><title>Journal of diabetes and its complications</title><addtitle>J Diabetes Complications</addtitle><description>Impaired blood flow to skin contributes to foot ulceration and amputation. The overall objective of this cross-sectional study was to examine the relationship between chronic physical activity and skin blood flow in Type 2 diabetes. To do so, diabetic and control subjects were separated into four groups based on a physical activity questionnaire: control exerciser (CE), control sedentary (CS), diabetic exerciser (DE), and diabetic sedentary (DS) subjects. After a physical exam and neuropathic testing, skin blood flow was measured noninvasively by continuous laser Doppler assessment of lower limb blood flow in response to various stimuli. Both groups of exercisers had enhanced baseline and ischemia reperfusion (IRP)-induced blood flow. Significant differences in maximal neurogenic dorsal foot skin perfusion were also present (
P<.05): CE had greater perfusion than either diabetic group, but CS blood flow was higher than DS only. Since, nitric oxide (NO) is a potent vasodilator, concurrent real-time measurements of NO in cutaneous interstitial fluids were recorded. No significant differences in maximal levels of NO were found among the four groups during any flow condition. Fasting serum glucose levels and HbA
1c were significantly inversely correlated with skin blood flow during heating. Chronic exercise is associated with enhanced skin blood under certain flow conditions in Type 2 diabetes compared with the sedentary state. As such, regular physical activity may be an invaluable tool in the prevention and reversal of defective skin vasodilation and resultant foot ulcers so common in diabetes.</description><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Blood flow</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Exercise - physiology</subject><subject>Exercise training</subject><subject>Female</subject><subject>Foot</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Male</subject><subject>Management. Various non-drug treatments. Langerhans islet grafts</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Regional Blood Flow - physiology</subject><subject>Skin - blood supply</subject><subject>Skin - innervation</subject><subject>Surveys and Questionnaires</subject><subject>Type 2 diabetes</subject><issn>1056-8727</issn><issn>1873-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEQx4Movj-Ckouih9U8N81JpPiCggcreAvZZJZGtpuabK1-e7cP8ehpZuA3M39-CJ1QckUJLa9fKJFlMVBMXRB6SQhjrFBbaJ8OFC9ESd62-_4X2UMHOb8TQkop6S7ao4xwzXW5j8bDSYptcBi-ILmQAYeMbc7RBduBx4vQTTC0E9u6fnLzzrYQ5xlXTYwe101c4NDi8fcMMMM-2Ao6yEdop7ZNhuNNPUSv93fj4WMxen54Gt6OCicE7wpfec-1HAhtFZVAasUH3knBGJWukpXWVekcEVJJbsFbkK6UgmqtGKso9_wQna_vzlL8mEPuzDRkB02zDmkUVaUQjPagXIMuxZwT1GaWwtSmb0OJWeo0K51m6coQalY6jer3TjcP5tUU_N_Wxl8PnG0Am51t6tR7CvmP41JrxpcBbtYc9Do-AySTXYCl05DAdcbH8E-UH4bbkRo</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Colberg, Sheri R</creator><creator>Stansberry, Kevin B</creator><creator>McNitt, Patricia M</creator><creator>Vinik, Aaron I</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Chronic exercise is associated with enhanced cutaneous blood flow in Type 2 diabetes</title><author>Colberg, Sheri R ; Stansberry, Kevin B ; McNitt, Patricia M ; Vinik, Aaron I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-dbdd395849a715e0f738dc542215cb5b99b6cc045753aedae5c654199722b13d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Blood flow</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Exercise - physiology</topic><topic>Exercise training</topic><topic>Female</topic><topic>Foot</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Male</topic><topic>Management. Various non-drug treatments. Langerhans islet grafts</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitric oxide</topic><topic>Regional Blood Flow - physiology</topic><topic>Skin - blood supply</topic><topic>Skin - innervation</topic><topic>Surveys and Questionnaires</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colberg, Sheri R</creatorcontrib><creatorcontrib>Stansberry, Kevin B</creatorcontrib><creatorcontrib>McNitt, Patricia M</creatorcontrib><creatorcontrib>Vinik, Aaron I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of diabetes and its complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colberg, Sheri R</au><au>Stansberry, Kevin B</au><au>McNitt, Patricia M</au><au>Vinik, Aaron I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic exercise is associated with enhanced cutaneous blood flow in Type 2 diabetes</atitle><jtitle>Journal of diabetes and its complications</jtitle><addtitle>J Diabetes Complications</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>16</volume><issue>2</issue><spage>139</spage><epage>145</epage><pages>139-145</pages><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>Impaired blood flow to skin contributes to foot ulceration and amputation. The overall objective of this cross-sectional study was to examine the relationship between chronic physical activity and skin blood flow in Type 2 diabetes. To do so, diabetic and control subjects were separated into four groups based on a physical activity questionnaire: control exerciser (CE), control sedentary (CS), diabetic exerciser (DE), and diabetic sedentary (DS) subjects. After a physical exam and neuropathic testing, skin blood flow was measured noninvasively by continuous laser Doppler assessment of lower limb blood flow in response to various stimuli. Both groups of exercisers had enhanced baseline and ischemia reperfusion (IRP)-induced blood flow. Significant differences in maximal neurogenic dorsal foot skin perfusion were also present (
P<.05): CE had greater perfusion than either diabetic group, but CS blood flow was higher than DS only. Since, nitric oxide (NO) is a potent vasodilator, concurrent real-time measurements of NO in cutaneous interstitial fluids were recorded. No significant differences in maximal levels of NO were found among the four groups during any flow condition. Fasting serum glucose levels and HbA
1c were significantly inversely correlated with skin blood flow during heating. Chronic exercise is associated with enhanced skin blood under certain flow conditions in Type 2 diabetes compared with the sedentary state. As such, regular physical activity may be an invaluable tool in the prevention and reversal of defective skin vasodilation and resultant foot ulcers so common in diabetes.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12039396</pmid><doi>10.1016/S1056-8727(01)00222-7</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis of Variance Biological and medical sciences Blood flow Cross-Sectional Studies Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Diabetic Nephropathies - physiopathology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise - physiology Exercise training Female Foot Humans Hyperglycemia Male Management. Various non-drug treatments. Langerhans islet grafts Medical sciences Middle Aged Nitric oxide Regional Blood Flow - physiology Skin - blood supply Skin - innervation Surveys and Questionnaires Type 2 diabetes |
| title | Chronic exercise is associated with enhanced cutaneous blood flow in Type 2 diabetes |
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