Chronic exercise is associated with enhanced cutaneous blood flow in Type 2 diabetes

Impaired blood flow to skin contributes to foot ulceration and amputation. The overall objective of this cross-sectional study was to examine the relationship between chronic physical activity and skin blood flow in Type 2 diabetes. To do so, diabetic and control subjects were separated into four groups based on a physical activity questionnaire: control exerciser (CE), control sedentary (CS), diabetic exerciser (DE), and diabetic sedentary (DS) subjects. After a physical exam and neuropathic testing, skin blood flow was measured noninvasively by continuous laser Doppler assessment of lower limb blood flow in response to various stimuli. Both groups of exercisers had enhanced baseline and ischemia reperfusion (IRP)-induced blood flow. Significant differences in maximal neurogenic dorsal foot skin perfusion were also present ( P