Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are...

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Veröffentlicht in:	Transgenic research 2000-04, Vol.9 (2), p.145-154
Hauptverfasser:	CHEN, A. S, METZGER, J. M, CAMACHO, R. E, STRACK, A. M, MELLIN, T. N, MACINTYRE, D. E, CHEN, H. Y, VAN DER PLOEG, L. H. T, TRUMBAUER, M. E, GUAN, X.-M, HONG YU, FRAZIER, E. G, MARSH, D. J, FORREST, M. J, GOPAL-TRUTER, S, FISHER, J
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-MSH - analogs & derivatives alpha-MSH - pharmacology Animals Basal Metabolism Biological and medical sciences Biotechnology Body Composition Body Weight - physiology Eating - physiology Fundamental and applied biological sciences. Psychology Genetic engineering Genetic technics In Situ Hybridization Male Medical sciences melanocortin 4 receptors melanotan II Metabolic diseases Metabolism Methods. Procedures. Technologies Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Obesity Peptides, Cyclic - pharmacology Receptor, Melanocortin, Type 4 Receptors, Peptide - genetics Receptors, Peptide - metabolism Rodents Transgenic animals Transgenic animals and transgenic plants Weight control
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Zusammenfassung:	We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.
ISSN:	0962-8819 1573-9368
DOI:	10.1023/a:1008983615045