Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning
Inbred rat strains for congenital learned helplessness (cLH) and for congenital resistance to learned helplessness (cNLH) were investigated as a model to study genetic predisposition to major depression. Congenitally helpless rats respond less to sucrose under a progressive ratio schedule. This is n...
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Veröffentlicht in: | Behavioural brain research 2004-04, Vol.150 (1), p.217-221 |
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creator | Vollmayr, Barbara Bachteler, Daniel Vengeliene, Valentina Gass, Peter Spanagel, Rainer Henn, Fritz |
description | Inbred rat strains for congenital learned helplessness (cLH) and for congenital resistance to learned helplessness (cNLH) were investigated as a model to study genetic predisposition to major depression. Congenitally helpless rats respond less to sucrose under a progressive ratio schedule. This is not confounded by locomotor hypoactivity: in contrast, cLH rats show a slight hyperactivity during the first 5
min of an open field test. cLH rats acquire operant responding to sucrose as readily as cNLH rats and exhibit normal memory acquisition and retrieval in the Morris water maze, thus ruling out general learning deficits as the cause of the decreased response to sucrose. Reduced total responses and reduced breaking points for sucrose in the cLH strain argue for anhedonia, which is an analogue to loss of pleasure essential for the diagnosis of major depressive episodes, and thus confirm the validity of congenitally learned helpless rats as a model of major depression. |
doi_str_mv | 10.1016/S0166-4328(03)00259-6 |
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min of an open field test. cLH rats acquire operant responding to sucrose as readily as cNLH rats and exhibit normal memory acquisition and retrieval in the Morris water maze, thus ruling out general learning deficits as the cause of the decreased response to sucrose. Reduced total responses and reduced breaking points for sucrose in the cLH strain argue for anhedonia, which is an analogue to loss of pleasure essential for the diagnosis of major depressive episodes, and thus confirm the validity of congenitally learned helpless rats as a model of major depression.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/S0166-4328(03)00259-6</identifier><identifier>PMID: 15033295</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Anhedonia ; Animal ; Animal model ; Animals ; Biological and medical sciences ; Conditioning ; Conditioning, Operant - drug effects ; Conditioning, Operant - physiology ; Depression ; Female ; Fundamental and applied biological sciences. Psychology ; Helplessness, Learned ; Learned helplessness ; Learning - physiology ; Learning. Memory ; Male ; Maze Learning - physiology ; Morris water maze ; Motor Activity - physiology ; Open field ; Operant behavior ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Reinforcement Schedule ; Reward ; Sucrose</subject><ispartof>Behavioural brain research, 2004-04, Vol.150 (1), p.217-221</ispartof><rights>2003 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-c209b8d724dcbdff622a6ab3969b11620b4d5f44a3fc791d26a39a01afabc7d43</citedby><cites>FETCH-LOGICAL-c474t-c209b8d724dcbdff622a6ab3969b11620b4d5f44a3fc791d26a39a01afabc7d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166432803002596$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15599684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15033295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vollmayr, Barbara</creatorcontrib><creatorcontrib>Bachteler, Daniel</creatorcontrib><creatorcontrib>Vengeliene, Valentina</creatorcontrib><creatorcontrib>Gass, Peter</creatorcontrib><creatorcontrib>Spanagel, Rainer</creatorcontrib><creatorcontrib>Henn, Fritz</creatorcontrib><title>Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Inbred rat strains for congenital learned helplessness (cLH) and for congenital resistance to learned helplessness (cNLH) were investigated as a model to study genetic predisposition to major depression. Congenitally helpless rats respond less to sucrose under a progressive ratio schedule. This is not confounded by locomotor hypoactivity: in contrast, cLH rats show a slight hyperactivity during the first 5
min of an open field test. cLH rats acquire operant responding to sucrose as readily as cNLH rats and exhibit normal memory acquisition and retrieval in the Morris water maze, thus ruling out general learning deficits as the cause of the decreased response to sucrose. Reduced total responses and reduced breaking points for sucrose in the cLH strain argue for anhedonia, which is an analogue to loss of pleasure essential for the diagnosis of major depressive episodes, and thus confirm the validity of congenitally learned helpless rats as a model of major depression.</description><subject>Anhedonia</subject><subject>Animal</subject><subject>Animal model</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Conditioning</subject><subject>Conditioning, Operant - drug effects</subject><subject>Conditioning, Operant - physiology</subject><subject>Depression</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Helplessness, Learned</subject><subject>Learned helplessness</subject><subject>Learning - physiology</subject><subject>Learning. Memory</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Morris water maze</subject><subject>Motor Activity - physiology</subject><subject>Open field</subject><subject>Operant behavior</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reinforcement Schedule</subject><subject>Reward</subject><subject>Sucrose</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9rb6E5RsFF2M5juTVZFiVSgIfqxDJjnTG5mbXJNMS_-9M70XdddFEgjPec8574vQC0reUULV--_LpTrBWf-G8LeEMGk69QhtaK9Zp6Uwj9HmL3KCTmv9RQgRRNKn6IRKwjkzcoPSN9cqvo1ti31O15BicxOewJUEAW9h2k9Qa1oOLlD3OQW8fuCWcZ19yRXwMDdct_kWp4wDjNHHRTEm7HyLN7Hd4VwOgjFdP0NPRjdVeH58z9DPy48_Lj53V18_fbn4cNV5oUXrPCNm6INmIvghjKNizCk3cKPMQKliZBBBjkI4PnptaGDKceMIdaMbvA6Cn6HXB919yb9nqM3uYvUwTS5BnqvVVEvaC_kgSLUxmtIVlAdwXboWGO2-xJ0rd5YSuyZi7xOxq92WcHufiFVL3ctjg3nYQfhXdYxgAV4dAVe9m8biko_1P04ao_p1pfMDB4tvNxGKrT5C8hBiAd9syPGBUf4AmZup7g</recordid><startdate>20040402</startdate><enddate>20040402</enddate><creator>Vollmayr, Barbara</creator><creator>Bachteler, Daniel</creator><creator>Vengeliene, Valentina</creator><creator>Gass, Peter</creator><creator>Spanagel, Rainer</creator><creator>Henn, Fritz</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040402</creationdate><title>Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning</title><author>Vollmayr, Barbara ; Bachteler, Daniel ; Vengeliene, Valentina ; Gass, Peter ; Spanagel, Rainer ; Henn, Fritz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-c209b8d724dcbdff622a6ab3969b11620b4d5f44a3fc791d26a39a01afabc7d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anhedonia</topic><topic>Animal</topic><topic>Animal model</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Conditioning</topic><topic>Conditioning, Operant - drug effects</topic><topic>Conditioning, Operant - physiology</topic><topic>Depression</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Helplessness, Learned</topic><topic>Learned helplessness</topic><topic>Learning - physiology</topic><topic>Learning. Memory</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Morris water maze</topic><topic>Motor Activity - physiology</topic><topic>Open field</topic><topic>Operant behavior</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reinforcement Schedule</topic><topic>Reward</topic><topic>Sucrose</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vollmayr, Barbara</creatorcontrib><creatorcontrib>Bachteler, Daniel</creatorcontrib><creatorcontrib>Vengeliene, Valentina</creatorcontrib><creatorcontrib>Gass, Peter</creatorcontrib><creatorcontrib>Spanagel, Rainer</creatorcontrib><creatorcontrib>Henn, Fritz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vollmayr, Barbara</au><au>Bachteler, Daniel</au><au>Vengeliene, Valentina</au><au>Gass, Peter</au><au>Spanagel, Rainer</au><au>Henn, Fritz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2004-04-02</date><risdate>2004</risdate><volume>150</volume><issue>1</issue><spage>217</spage><epage>221</epage><pages>217-221</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Inbred rat strains for congenital learned helplessness (cLH) and for congenital resistance to learned helplessness (cNLH) were investigated as a model to study genetic predisposition to major depression. Congenitally helpless rats respond less to sucrose under a progressive ratio schedule. This is not confounded by locomotor hypoactivity: in contrast, cLH rats show a slight hyperactivity during the first 5
min of an open field test. cLH rats acquire operant responding to sucrose as readily as cNLH rats and exhibit normal memory acquisition and retrieval in the Morris water maze, thus ruling out general learning deficits as the cause of the decreased response to sucrose. Reduced total responses and reduced breaking points for sucrose in the cLH strain argue for anhedonia, which is an analogue to loss of pleasure essential for the diagnosis of major depressive episodes, and thus confirm the validity of congenitally learned helpless rats as a model of major depression.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>15033295</pmid><doi>10.1016/S0166-4328(03)00259-6</doi><tpages>5</tpages></addata></record> |
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subjects | Anhedonia Animal Animal model Animals Biological and medical sciences Conditioning Conditioning, Operant - drug effects Conditioning, Operant - physiology Depression Female Fundamental and applied biological sciences. Psychology Helplessness, Learned Learned helplessness Learning - physiology Learning. Memory Male Maze Learning - physiology Morris water maze Motor Activity - physiology Open field Operant behavior Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Reinforcement Schedule Reward Sucrose |
title | Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning |
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