Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning

Inbred rat strains for congenital learned helplessness (cLH) and for congenital resistance to learned helplessness (cNLH) were investigated as a model to study genetic predisposition to major depression. Congenitally helpless rats respond less to sucrose under a progressive ratio schedule. This is n...

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Veröffentlicht in:Behavioural brain research 2004-04, Vol.150 (1), p.217-221
Hauptverfasser: Vollmayr, Barbara, Bachteler, Daniel, Vengeliene, Valentina, Gass, Peter, Spanagel, Rainer, Henn, Fritz
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container_end_page 221
container_issue 1
container_start_page 217
container_title Behavioural brain research
container_volume 150
creator Vollmayr, Barbara
Bachteler, Daniel
Vengeliene, Valentina
Gass, Peter
Spanagel, Rainer
Henn, Fritz
description Inbred rat strains for congenital learned helplessness (cLH) and for congenital resistance to learned helplessness (cNLH) were investigated as a model to study genetic predisposition to major depression. Congenitally helpless rats respond less to sucrose under a progressive ratio schedule. This is not confounded by locomotor hypoactivity: in contrast, cLH rats show a slight hyperactivity during the first 5 min of an open field test. cLH rats acquire operant responding to sucrose as readily as cNLH rats and exhibit normal memory acquisition and retrieval in the Morris water maze, thus ruling out general learning deficits as the cause of the decreased response to sucrose. Reduced total responses and reduced breaking points for sucrose in the cLH strain argue for anhedonia, which is an analogue to loss of pleasure essential for the diagnosis of major depressive episodes, and thus confirm the validity of congenitally learned helpless rats as a model of major depression.
doi_str_mv 10.1016/S0166-4328(03)00259-6
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subjects Anhedonia
Animal
Animal model
Animals
Biological and medical sciences
Conditioning
Conditioning, Operant - drug effects
Conditioning, Operant - physiology
Depression
Female
Fundamental and applied biological sciences. Psychology
Helplessness, Learned
Learned helplessness
Learning - physiology
Learning. Memory
Male
Maze Learning - physiology
Morris water maze
Motor Activity - physiology
Open field
Operant behavior
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Sprague-Dawley
Reinforcement Schedule
Reward
Sucrose
title Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning
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