Selamectin: a novel broad-spectrum endectocide for dogs and cats

Selamectin, 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide, is a novel endectocide with a unique combination of efficacy and safety in dogs and cats following both oral and topical administration. The compound is active against fleas and ticks...

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Veröffentlicht in:	Veterinary parasitology 2000-08, Vol.91 (3), p.163-176
Hauptverfasser:	Bishop, B.F, Bruce, C.I, Evans, N.A, Goudie, A.C, Gration, K.A.F, Gibson, S.P, Pacey, M.S, Perry, D.A, Walshe, N.D.A, Witty, M.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Antiparasitic Agents - administration & dosage Antiparasitic Agents - therapeutic use avermectin Cat Diseases - drug therapy Cats Ctenocephalides felis Dirofilaria immitis Dog Diseases - drug therapy Dogs Dose-Response Relationship, Drug Drug Administration Schedule Ectoparasitic Infestations - drug therapy Ectoparasitic Infestations - veterinary Endectocide Female Gastrointestinal nematodes Ivermectin - analogs & derivatives Ivermectin - therapeutic use Male Selamectin Siphonaptera - drug effects Ticks
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Beschreibung
Zusammenfassung:	Selamectin, 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide, is a novel endectocide with a unique combination of efficacy and safety in dogs and cats following both oral and topical administration. The compound is active against fleas and ticks, intestinal hookworms and ascarids, and immature heartworms. Also it is well tolerated at higher dosages than 22,23-dihydroavermectin B1a (DHAVM) or milbemycin oxime in Collies, which is a breed known to exhibit idiosyncratic sensitivity to avermectins.
ISSN:	0304-4017 1873-2550
DOI:	10.1016/S0304-4017(00)00289-2