Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?

Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta lo...

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Veröffentlicht in:	Neurology 2002-05, Vol.58 (10), p.1566-1568
Hauptverfasser:	GREEN, E. K, HARRIS, J. M, LEMMON, H, LAMBERT, J. C, CHARTIER-HARLIN, M. C, CLAIR, D. St, MANN, D. M. A, IWATSUBO, T, LENDON, C. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Aged Aged, 80 and over Alzheimer Disease - genetics Analysis of Variance Biological and medical sciences Chi-Square Distribution Cohort Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Gene Frequency - genetics Genotype Humans Interleukin-1 - genetics Male Medical sciences Middle Aged Neurology Polymorphism, Genetic - genetics Risk Factors
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Zusammenfassung:	Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B(-511) on Abeta(40) load (p < 0.05) was detected.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.58.10.1566