Association of t(9;11)-MLL AF9 and Trisomy 8 in an AML-M5 Preceded by Pancytopenia

Association of t(9;11)-MLL AF9 and Trisomy 8 in an AML-M5 Preceded by Pancytopenia

The implication of MLL gene rearrangements in the prognosis of acute myeloblastic leukemia is an issue of considerable current interest. We report a case of a young man who initially presented with a pancytopenia and went on to develop a highly-aggressive acute myeloblastic leukemia. At this time, t...

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Veröffentlicht in:Cancer genetics and cytogenetics 2000-07, Vol.120 (2), p.144-147
Hauptverfasser: Anguita, E, Barrio, C.G, González, F.A, Ferro, M.T, del Potro, E, Ropero, P, Villegas, A
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Blotting, Southern
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 8 - genetics
Chromosomes, Human, Pair 9 - genetics
Cytogenetic Analysis
DNA, Neoplasm - genetics
DNA-Binding Proteins - genetics
Hematologic and hematopoietic diseases
Histone-Lysine N-Methyltransferase
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Monocytic, Acute - genetics
Leukemia, Monocytic, Acute - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Myeloid-Lymphoid Leukemia Protein
Nuclear Proteins - genetics
Oncogene Proteins, Fusion - genetics
Pancytopenia - genetics
Pancytopenia - pathology
Proto-Oncogenes
Transcription Factors
Translocation, Genetic
Trisomy
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Zusammenfassung:The implication of MLL gene rearrangements in the prognosis of acute myeloblastic leukemia is an issue of considerable current interest. We report a case of a young man who initially presented with a pancytopenia and went on to develop a highly-aggressive acute myeloblastic leukemia. At this time, the karyotypic study revealed trisomy 8, a t(9;11) was demonstrated by fluorescence in situ hybridization (FISH) and the MLL/AF4 rearrangement by reverse transcriptase-polymerase chain reaction (RT-PCR).
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(99)00260-5