Socializing with the Neighbors: Stem Cells and Their Niche

The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so, it is essential to understand how stem cells interact with their microenvironment, the so-called stem...

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Veröffentlicht in:	Cell 2004-03, Vol.116 (6), p.769-778
Hauptverfasser:	Fuchs, Elaine, Tumbar, Tudorita, Guasch, Geraldine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion Molecules - physiology Cell Communication - physiology Cell Differentiation - physiology Cell Division - physiology Cell Lineage - physiology Embryo, Mammalian - cytology Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryo, Mammalian - ultrastructure Humans Organogenesis - physiology Signal Transduction - physiology Stem Cells - metabolism Stem Cells - ultrastructure
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Beschreibung
Zusammenfassung:	The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so, it is essential to understand how stem cells interact with their microenvironment, the so-called stem cell niche, to establish and maintain their properties. In this review, we examine adult stem cell niches and their impact on stem cell biology.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/S0092-8674(04)00255-7