Evaluation of hypoglycemic and antihyperglycemic effects of Datura metel (Linn.) seeds in normal and alloxan-induced diabetic rats

The seed powder of Datura metel was tested for its hypoglycemic activity in normal and alloxan-induced diabetic rats. Graded doses (25, 50 and 75 mg/kg, p.o.) of the seed powder when given to both normal and diabetic rats produced significant reduction in blood glucose at the 8 h. The effect was fou...

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Veröffentlicht in:	Journal of ethnopharmacology 2004-03, Vol.91 (1), p.95-98
Hauptverfasser:	Krishna Murthy, B, Nammi, S, Kota, M.K, Krishna Rao, R.V, Koteswara Rao, N, Annapurna, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan Animals Ayurvedic medicine Biological and medical sciences Blood glucose Blood Glucose - drug effects Datura Datura metel Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Drug Evaluation experimental diabetes Female General pharmacology glycemic effect herbal medicines Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - therapeutic use Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Preparations - therapeutic use Rats Rats, Wistar Seeds traditional medicine
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Zusammenfassung:	The seed powder of Datura metel was tested for its hypoglycemic activity in normal and alloxan-induced diabetic rats. Graded doses (25, 50 and 75 mg/kg, p.o.) of the seed powder when given to both normal and diabetic rats produced significant reduction in blood glucose at the 8 h. The effect was found to be dose dependent with all treatments at the doses administered.
ISSN:	0378-8741 1872-7573
DOI:	10.1016/j.jep.2003.12.010