Total Synthesis and Stereochemical Assignment of Myriaporones 1, 3, and 4

Two stereoselective aldol reactions, a nitrile oxide cycloaddition, and a stereoselective late‐stage epoxidation were key steps in the total synthesis of myriaporones 1, 3, and 4 (see scheme). The synthesis allowed the unambiguous assignment of stereogenic centers not previously assigned for these c...

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Veröffentlicht in:	Angewandte Chemie International Edition 2004-03, Vol.43 (13), p.1728-1730
Hauptverfasser:	Fleming, Kristen N., Taylor, Richard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	aldol reaction Alkenes - chemical synthesis Alkenes - chemistry diastereoselectivity epoxidation Epoxy Compounds - chemical synthesis Epoxy Compounds - chemistry Molecular Conformation natural products Pyrans - chemical synthesis Pyrans - chemistry Stereoisomerism total synthesis
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Beschreibung
Zusammenfassung:	Two stereoselective aldol reactions, a nitrile oxide cycloaddition, and a stereoselective late‐stage epoxidation were key steps in the total synthesis of myriaporones 1, 3, and 4 (see scheme). The synthesis allowed the unambiguous assignment of stereogenic centers not previously assigned for these compounds.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200353348